Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates [PDF]
Journal of the Formosan Medical Association, 2008 First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho +6 more
doaj +6 more sources
The Absorption Characteristics of Nonvolatile Components in a Water Extraction From Amomi fructus as Determined by In Situ Single-Pass Intestinal Perfusion and High-Performance Liquid Chromatography [PDF]
Frontiers in Pharmacology, 2020 BackgroundAmomi fructus is a famous traditional Chinese medicine (TCM) that can exert beneficial effects during the treatment of gastrointestinal diseases and is used widely in China and other countries in Southeast Asia.
Yuebao Yao +7 more
doaj +3 more sources
Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC) [PDF]
Molecules, 2017 In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ).
Guojun Kuang +9 more
doaj +3 more sources
Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models. [PDF]
Acta Pharmacol Sin, 2012 Aim:To investigate the mechanisms underlying the intestinal absorption of the major bioactive component forsythoside A (FTA) extracted from Forsythiae fructus.Methods:An in vitro Caco-2 cell model and a single-pass intestinal perfusion in situ model in ...
Zhou W +6 more
europepmc +5 more sources
Indian J Pharm Sci, 2010 Previously, permeability and site of intestinal absorption of propranolol have been reported using the Ussing chamber. In the present study, the utility of Single-Pass Intestinal Perfusion to study permeability and site of intestinal absorption of ...
Nagare N +6 more
europepmc +5 more sources
Absorption characteristic of paeoniflorin-6′-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats [PDF]
Xenobiotica, 2016 1. Paeoniflorin-6′-O-benzene sulfonate (CP-25) was synthesized to improve the poor oral absorption of paeoniflorin (Pae). 2. This study was performed to investigate the absorptive behavior and mechanism of CP-25 in in situ single-pass intestinal ...
Xiao-dan Yang +6 more
semanticscholar +3 more sources
Biomedicine & Pharmacotherapy, 2018 Araloside A is a triterpenoid saponin,which exhibits a broad spectrum of pharmacological activities, such as stimulating fibrinolysis, preventing coagulant, inhibiting renin, and decreasing blood pressure. Our previous report found that the compound exhibits a poor absolute bioavailability.
Hui Yang +6 more
semanticscholar +3 more sources
Journal of Pharmaceutical and Biopharmaceutical Research, 2019 Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS).
Ye-jun Chen +6 more
semanticscholar +3 more sources
Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation [PDF]
Nature CommunicationsTrillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals.
Yu-Hang Zhang +7 more
doaj +2 more sources
Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies [PDF]
Drug Delivery, 2015 Trans-resveratrol (t-RVT) is a potent antioxidant. By virtue of extensive pre-systemic metabolism and existence of enterohepatic recirculation, t-RVT bioavailability is almost zero. The current study aimed to develop self-nanoemulsifying drug delivery systems (SNEDDS) using long-chain triglycerides (LCTs) of t-RVT in an attempt to circumvent such ...
Gurinder Singh, R. Pai
semanticscholar +3 more sources