Assessment of absorption of four lignan constituents of JingNing particles in rat gut using in situ single-pass intestinal perfusion [PDF]
Tropical Journal of Pharmaceutical Research, 2017 Purpose: To study small intestinal absorption of schisadrol A, schisandrol B, schizandrin A and schisandrin B in JingNing particles using in situ single-pass intestinal perfusion (SPIP).
Chunjing Yang +10 more
semanticscholar +5 more sources
Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique [PDF]
Pharmaceutics, 2021 Oleacein (OLEA) is one of the most important phenolic compounds in extra virgin olive oil in terms of concentration and health-promoting properties, yet there are insufficient data on its absorption and metabolism.
Anallely López-Yerena +5 more
doaj +3 more sources
Intestinal Absorption Mechanisms of Five Flavonoids from Malus hupehensis (Pamp.) Rehd. Extracts in Situ Single-Pass Intestinal Perfusion and in Vitro Caco-2 Cell Model [PDF]
, 2020 Background: Previous studies have shown that Malus hupehensis (Pamp.) Rehd. extracts have anti-oxidant, anti-aging and other effects, its bioavailability is low, however its absorption mechanism is still unclear.
Hui Yang +7 more
semanticscholar +2 more sources
Effect of Berbamine Hydrochloride on Absorption Parameters of Berberine Hydrochloride Based on in Situ Single-Pass Intestinal Perfusion System in the Rat [PDF]
, 2020 Background:Berberine is a kind of chemical that has obvious effects of lowering blood sugar, lowering blood lipid. The high toxicity of intravenous administration of berberine hydrochloride(BBH), it is only used for oral administration in clinic,but it
Jie Gao +7 more
semanticscholar +2 more sources
Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]
PharmaceuticalsCytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said +4 more
doaj +2 more sources
European Journal of Pharmaceutical Sciences, 2013 In order to reach the bloodstream and thus the target receptor, an orally-administered drug must first cross the intestinal barrier, which can occur via a paracellular, passive transcellular, or carrier-mediated uptake and/or efflux process (active or concentration gradient-driven).
Juliana Mazza Reis +4 more
semanticscholar +3 more sources
Effect of berbamine hydrochloride on the absorption of berberine hydrochloride in an in situ single-pass intestinal perfusion system in rats [PDF]
Tropical Journal of Pharmaceutical Research, 2022 Purpose: To investigate the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats.Methods: Based on the in situ single-pass intestinal perfusion model of rats, HPLC was used to determine the content of berberine hydrochloride in solution after perfusion under different conditions.
Tang, Xi +7 more
openaire +4 more sources
Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei +2 more
doaj +1 more source
Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption
Frontiers in Pharmacology, 2021 Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC).
Jingyao Wei +13 more
doaj +1 more source