Results 21 to 30 of about 11,428 (247)

Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

Pharmaceutics, 2020
In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by an ionic gelation method. The chitosan (CS) concentration, pH of the CS solution, sodium tripolyphosphate (TPP) concentration, stirring speed ...
Jie Yan, Zhi-Yu Guan, Wei-Feng Zhu, Ling-Yun Zhong, Zhuo-Qi Qiu, Peng-Fei Yue, Wen-Ting Wu, Jing Liu, Xiao Huang   +8 more
doaj   +1 more source

Opuntia dillenii (Ker Gawl.) Haw., Seeds Oil Antidiabetic Potential Using In Vivo, In Vitro, In Situ, and Ex Vivo Approaches to Reveal Its Underlying Mechanism of Action

Molecules, 2021
Opuntia dillenii Ker Gawl. is one of the medicinal plants used for the prevention and treatment of diabetes mellitus (DM) in Morocco. This study aims to investigate the antihyperglycemic effect of Opuntia dillenii seed oil (ODSO), its mechanism of action,
Mohamed Bouhrim, Hayat Ouassou, Salima Boutahiri, Nour Elhouda Daoudi, Hamza Mechchate, Bernard Gressier, Bruno Eto, Hamada Imtara, Amal A. Alotaibi, Mohammed Al-zharani, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham   +14 more
doaj   +1 more source

The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: P-glycoprotein (P-gp) plays a major role in oral absorption of drugs. Induction or inhibition of P-gp by drugs contributes to variability of its transport activity and often results in clinically relevant drug-drug interactions.
Mehran Mesgari Abbasi, Hadi Valizadeh, Hamed Hamishekar, Leila Mohammadnejad, Parvin Zakeri-Milani   +4 more
doaj   +1 more source

Regional Absorption of Fimasartan in the Gastrointestinal Tract by an Improved In Situ Absorption Method in Rats

Pharmaceutics, 2018
The aim of the present study was to assess the regional absorption of fimasartan by an improved in situ absorption method in comparison with the conventional in situ single-pass perfusion method in rats.
Tae Hwan Kim, Soo Heui Paik, Yong Ha Chi, Jürgen B. Bulitta, Da Young Lee, Jun Young Lim, Seung Eun Chung, Chang Ho Song, Hyeon Myeong Jeong, Soyoung Shin, Beom Soo Shin   +10 more
doaj   +1 more source

Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion [PDF]

, 2018
Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected.
Graham, V., Kenward, H., Lucas, M., McColl, S., McNaughton, E., Sabir, S., Tainsh, P., Turkington, C., Watson, P.   +8 more
core   +1 more source

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

Acta Pharmaceutica Sinica B, 2014
The aim of this study was to develop a formulation to improve the oral absorption of baicalin (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA–PC–SMEDDS.
Huiyi Wu, Xiaoying Long, Fei Yuan, Li Chen, Sujing Pan, Yunjun Liu, Yoshiko Stowell, Xiaoling Li   +7 more
doaj   +1 more source

The Effect of Particle Size on the Absorption of Cyclosporin A Nanosuspensions

International Journal of Nanomedicine, 2022
Wenjun Sun,1 Jing Gao,1 Ranran Fan,2 Ting Zhang,3 Yang Tian,1 Zengming Wang,1 Hui Zhang,1 Aiping Zheng1 1Department of Pharmaceutics, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, People’s Republic of China ...
Sun W, Gao J, Fan R, Zhang T, Tian Y, Wang Z, Zhang H, Zheng A   +7 more
doaj  

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +3 more sources

FROG INTESTINAL PERFUSION TO EVALUATE DRUG PERMEABILITY: APPLICATION TO P-gp AND CYP3A4 SUBSTRATES

Frontiers in Pharmacology, 2015
To evaluate the reliability of using in situ frog intestinal perfusion technique for permeability assessment of carrier transported drugs which are also substrates for CYP enzymes.
Neelima eYerasi, krishna edevarakonda, Himabindu evurimindi   +2 more
doaj   +1 more source

Biowaiver Monographs for Immediate‐Release Solid Oral Dosage Forms: Codeine Phosphate [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106898/1/jps23977 ...
Abrahamsson, Bertil, Amidon, Gordon L., Cristofoletti, Rodrigo, Dahan, Arik, Dressman, Jennifer B., Groot, D. W., Kopp, Sabine, Langguth, Peter, Polli, James E., Shah, Vinod P., Wolk, Omri, Zur, Moran   +11 more
core   +1 more source