Results 51 to 60 of about 8,610,712 (380)

Efficacy and Safety of Platelet Inhibitors

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Ischemic heart disease is the second leading cause of death in the world. The proportion of deaths resulting from this condition has decreased in the last two decades, mainly as a result of improved primary and secondary prevention of cardiovascular ...
Ornella Binazon, Audrey Dubois-Gauche, Radu M Nanau, Manuela G Neuman   +3 more
doaj   +1 more source

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

Frontiers in Bioengineering and Biotechnology, 2020
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern.
K. Kitaeva, Catrin Rutland, A. Rizvanov, V. Solovyeva   +3 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Muscle stem cell isolation and in vitro culture for meat production: A methodological review.

Comprehensive Reviews in Food Science and Food Safety, 2020
Cultured muscle tissue-based protein products, also known as cultured meat, are produced through in vitro myogenesis involving muscle stem cell culture and differentiation, and mature muscle cell processing for flavor and texture.
Kwang-Hwan Choi, J. Yoon, Minsu Kim, H. Lee, Jinsol Jeong, Minkyung Ryu, C. Jo, Chang-Kyu Lee   +7 more
semanticscholar   +1 more source

Scaffolds for 3D in vitro culture of neural lineage cells. [PDF]

, 2017
Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries.
Cameron, Neil R., Laslett, Andrew, Murphy, Ashley R., O'Brien, Carmel M.   +3 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

In vitro Ploidy Manipulation for Crop Improvement

Frontiers in Plant Science, 2020
In vitro regeneration systems provide a powerful tool for manipulating ploidy to facilitate breeding and development of new crops. Polyploid induction can expand breeding opportunities, assist with the development of seedless triploid cultivars, enhance ...
D. Touchell, Irene E. Palmer, T. Ranney
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Burden of non-COVID-19 lower respiratory infections in China (1990–2021): a global burden of disease study analysis

Respiratory Research
Background The assessment of lower respiratory infection (LRI) mortality, incidence, and responsible pathogens in China provides a scientific basis for the prevention and management of LRI, especially for evaluating the impact of coronavirus disease 2019
Manyu Li, Zeyu Song, Wenjun Wan, Haiwei Zhou   +3 more
doaj   +1 more source

Effectiveness of in vitro maturation and in vitro fertilization techniques in pigs.

Journal of reproduction and fertility. Supplement, 2020
In vitro maturation and in vitro fertilization techniques in pigs have progressed considerably in recent years. Many reports focus on the factors affecting in vitro maturation that lead to normal male pronuclear formation or monospermy after ...
K. Niwa
semanticscholar   +1 more source