Results 141 to 150 of about 117,958,750 (306)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Influence of calcium propionate on in vitro fermentation of sorghum-based diets

Revista de la Facultad de Ciencias Agrarias, 2017
The objective of the present study was to evaluate the effect of calcium propionate (CaPr) on in vitro ruminal fermentation using a factorial arrangement 2 x 2 evaluating CaPr (0 vs. 1%) and grain level (55 vs. 65%). There was a CaPr x Grain interaction
Luis Alberto Miranda, Héctor Aarón Lee-Rangel, Germán David Mendoza-Martínez, María Magdalena Crosby-Galván, Alejandro Enrique Relling, Juan Manuel Pinos-Rodríguez, Rolando Rojo Rubio, Milagros González Hernandez   +7 more
doaj  

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Effect of different forage-to-concentrate ratios on in vitro fermentation.

, 2019
Effect of different forage-to-concentrate ratios on in vitro fermentation.
Chaoli Lang (6725465), Mohammed Hamdy Farouk (6725477), Weiguang Zhong (6725471), Xiaogang Yan (1485523), Huaming Yang (1700539), Haizhu Zhou (6725468), Zhibin Ban (6725474), Runhang Li (6725459), Zhanwei Teng (6725462), Yujie Lou (6725480)   +9 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Degradation of Anti-Nutritional Factors in Maize Gluten Feed by Fermentation with Bacillus subtilis: A Focused Study on Optimizing Fermentation Conditions

Maize gluten feed is rich in micronutrients and serves as a good source of protein and dietary fiber, but also contains anti-nutritional factors.
Jianfen Liang, Xiaohong Sun, Lei Ma, Yaoquan Xuan   +3 more
core   +1 more source

Bioaccessibility and bioactivities of phenolic compounds from microalgae during in vitro digestion and colonic fermentation

, 2022
Conceptual framework of the microalgae in vitro digestion and colonic ...
GJO Martin (14597312), K Li (8012927), DRA Hill (14597309), Hafiz Suleria (13096467), L Zhou (7644107), X Duan (9884207)   +5 more
core  

The effect of selective quinoa varieties (Chenopodium quinoa willd.) on in vitro rumen fermentation and methane production

Journal of Applied Animal Research
The study compared the effects of three quinoa varieties, Titicaca (QA), Vikinga (QB), Zeno (QC) with those of other regularly used forages: whole wheat crop (WWC), alfalfa forage (AF), mixed grass forage (FG), on in vitro gas production, methane (CH4 ...
Ewa Pecka-Kiełb, Bożena Króliczewska, Barbara Król, Maja Słupczyńska, Józef Sowiński, Andrzej Zachwieja, Jowita Kaszuba, František Zigo   +7 more
doaj   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

The Effects of Fermentation Time and the Addition of Blueberry on the Texture Properties and In Vitro Digestion of Whey Protein Gel

The interaction of blueberry and whey protein has strong antioxidant properties and potential antibacterial and anti-aging functions during the fermentation process.
Zhangwei He, Yuxian Wang, Yufeng Shao, Qian Yu, Congcong Tang, Wenqiong Wang, Xian Liu   +6 more
core   +1 more source