Results 51 to 60 of about 332,871 (312)

Tumor-microenvironment-on-a-chip: the construction and application

Cell Communication and Signaling
Currently, despite the vast amounts of time and money invested in cancer treatment, cancer remains one of the primary threats to human life. The primary factor contributing to the low treatment efficacy is cancer heterogeneity.
Hanzheng Xu, Jiangtao Wen, Jiahua Yang, Shufen Zhou, Yijie Li, Ke Xu, Wei Li, Sen Li   +7 more
doaj   +1 more source

Exploring bone-tumor interactions through 3D in vitro models: Implications for primary and metastatic cancers

Journal of Bone Oncology
Bone tissue serves as a perfect hosting site where metastatic cancer cells of the most prevalent cancer types, such as prostate and breast cancers, as well as the native bone sarcomas, can further proliferate, advancing the disease stage with the ...
Nicolas Cristini, Mohamadreza Tavakoli, Mehdi Sanati, Saber Amin Yavari   +3 more
doaj   +1 more source

In vitro models of breast cancer bone metastasis: analyzing drug resistance through the lens of the microenvironment

Frontiers in Oncology, 2023
Even though breast cancers usually have a good outcome compared to other tumors, the cancer can progress and create metastases in different parts of the organism, the bone being a predilection locus.
Anaïs Lamouline, Anaïs Lamouline, Anaïs Lamouline, Simone Bersini, Simone Bersini, Simone Bersini, Matteo Moretti, Matteo Moretti, Matteo Moretti, Matteo Moretti   +9 more
doaj   +1 more source

Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages [PDF]

, 2023
Camila Sales Nascimento, Naiara Clemente Tavares, Izabella Cristina Andrade Batista, Mônica Maria Magalhães Caetano, Eneida Santos de Oliveira, Stella Garcia Colombarolli, Anna Carolina Pinheiro Lage, Rodrigo Corrêa‐Oliveira, Érica Alessandra Rocha Alves, Celso P. de Melo, Carlos Eduardo Calzavara-Silva   +10 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio
The hallmarks of cancer extend beyond genetic anomalies to encompass a sophisticated tumor microenvironment, involving interactions between cancer and non‐cancer cells within a dynamic biophysical setting, influencing cancer progression.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
doaj   +1 more source

Impact of hysteroscopic tubal occlusion on the uterine microenvironment and pregnancy outcomes in tubal factor infertility

The Journal of Maternal-Fetal & Neonatal Medicine
Background Hysteroscopic tubal occlusion serves as an effective minimally invasive treatment, aiming to improve the efficacy of assisted reproductive technologies by preventing hydrosalpinx fluid from entering the uterine cavity.
Yiling Cai, Chengrong Wu, Ying Song, Shunfang Wang, Li Sun, Hualei Cai   +5 more
doaj   +1 more source

Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments

JOR Spine, 2022
Background It is well established that the unique biochemical microenvironment of the intervertebral disc plays a predominant role in cell viability and biosynthesis.
Emily E. McDonnell, Conor T. Buckley
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source