3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures
Bio-Protocol, 2023 Human neuromuscular diseases represent a diverse group of disorders with unmet clinical need, ranging from muscular dystrophies, such as Duchenne muscular dystrophy (DMD), to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS).
Peter Harley +5 more
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In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and LimitationsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver
Young-Sun Lee, Ekihiro Seki
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Clinically relevant in vitro biofilm models: A need to mimic and recapitulate the host environment
Biofilm, 2022 Biofilm-associated infections are difficult to treat and eradicate because of their increased antimicrobial tolerance. In vitro biofilm models have enabled the high throughput testing of an array of differing novel antimicrobials and treatment strategies.
Heema Kumari Nilesh Vyas +2 more
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In Vitro and In Vivo Models to Study the Zoonotic Mosquito-Borne Usutu Virus
Viruses, 2020 Usutu virus (USUV), a mosquito-borne zoonotic flavivirus discovered in South Africa in 1959, has spread to many European countries over the last 20 years.
Emna Benzarti, Mutien Garigliany
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In vitro Modeling of Chicken Cecal Microbiota Ecology and Metabolism Using the PolyFermS Platform
Frontiers in Microbiology, 2021 Continuous in vitro fermentation models provide a useful tool for a fast, reproducible, and direct assessment of treatment-related changes in microbiota metabolism and composition independent of the host.
Paul Tetteh Asare +7 more
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Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability
Sci, 2021 There is a growing need for novel in vitro corneal models to replace animal-based ex vivo tests in drug permeability studies. In this study, we demonstrated a corneal mimetic that models the stromal and epithelial compartments of the human cornea.
Agnė Žiniauskaitė +8 more
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In Vitro and In Vivo Models for Evaluating the Oral Toxicity of Nanomedicines
Nanomaterials, 2020 Toxicity studies for conventional oral drug formulations are standardized and well documented, as required by the guidelines of administrative agencies such as the US Food & Drug Administration (FDA), the European Medicines Agency (EMA) or European ...
Sudeep Lama +2 more
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Raziskovalni modeli raka sečnega mehurja za izboljšanje diagnostike in zdravljenja
Zdravniški Vestnik, 2020 Rak sečnega mehurja je ena najpogostejših rakavih bolezni pri moških in ima visoko stopnjo ponovljivosti, zaradi česar predstavlja velik ekonomski in socialni problem.
Daša Zupančič, Samo Hudoklin
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Animals, 2022 Bladder cancer (BC) constitutes approximately 2% of all spontaneously occurring cancers in dogs. It is characterized by a devastating clinical course in most cases, which emphasizes a constant need for the development of novel methods of disease ...
Łukasz Nowak +4 more
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Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
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