Results 31 to 40 of about 1,720,158 (168)
Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines
Advanced Biomedical Research, 2016 Background: Cell culture techniques have many advantages for investigation of drug transport to target organ like liver. HepG2 and Huh-7 are two cell lines available from hepatoma that can be used as a model for hepatic drug transport.
Melva Louisa +4 more
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In Vitro Human Liver Model for Toxicity Assessment with Clinical and Preclinical Instrumentation
PharmaceuticsThe existing in vitro toxicological models lack translational potential, which makes difficult the application of gathered information to clinical usage.
Eneko Madorran +3 more
doaj +1 more source
Animals, 2021 Scrapie is a prion disease affecting sheep and goats and it is considered a prototype of transmissible spongiform encephalopathies (TSEs). Mesenchymal stem cells (MSCs) have been proposed as candidates for developing in vitro models of prion diseases ...
Laura García-Mendívil +12 more
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Modelling germ cell development in vitro [PDF]
Molecular Human Reproduction, 2008 Germ cells have a critical role in mediating the generation of genetic diversity and transmitting this information across generations. Furthermore, gametogenesis is unique as a developmental process in that it generates highly-specialized haploid gametes from diploid precursor stem cells through meiosis. Despite the importance of this process, progress
Childs, Andrew J +2 more
openaire +3 more sources
Micro & Nano Letters, 2023 The chronic lesion has become a major biological difficulty. Using nanoparticles as drug delivery systems is remarkable nowadays. The unique properties of chitosan in combination with epidermal growth factor (EGF) can accelerate the wound‐healing process.
Saadeh Hashemi +2 more
doaj +1 more source
Diagnostics, 2021 Static mechanical compression is a biomechanical factor that affects the progression of melanoma cells. However, little is known about how dynamic mechanical compression affects the progression of melanoma cells.
Takashi Morikura, Shogo Miyata
doaj +1 more source
Myocardial Tissue Engineering: In Vitro Models [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Modeling integrated human physiology in vitro is a formidable task not yet achieved with any of the existing cell/tissue systems. However, tissue engineering is becoming increasingly successful at authentic representation of the actual environmental milieu of tissue development, regeneration and disease progression, and in providing real-time insights ...
G. Vunjak Novakovic +2 more
openaire +3 more sources
In vitro models of intracerebral hemorrhage
Brain Hemorrhages, 2022 Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research.
Bilal Syed, Abhijit Nirwane, Yao Yao
openaire +3 more sources
Development of idealized human aortic models for in vitro and in silico hemodynamic studies
Frontiers in Cardiovascular MedicineBackgroundThe aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies.ObjectiveThis study ...
Hamid Mansouri +4 more
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In vitro models for investigating itch
Frontiers in Molecular Neuroscience, 2022 Itch (pruritus) is a sensation that drives a desire to scratch, a behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch is a hallmark symptom and in which prolonged scratching can induce damage.
Hendrik Mießner +3 more
openaire +3 more sources