Results 181 to 190 of about 1,346,069 (268)

Chiropteran (<i>Hypsugo savii</i>) Post-Natal Brain 2D-In Vitro Models: Primary Cell Isolation, Immortalization and Transcriptomic Changes. [PDF]

Animals (Basel)
Molinari A, Moccia V, Babbucci M, Peruzza L, Negrisolo E, Centelleghe C, Mazzariol S, Zappulli VEG.   +7 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Ranalexin-1G: A Promising Antimicrobial Peptide Targeting Virulence and Host-Pathogen Interactions in <i>Pseudomonas aeruginosa</i> In Vitro Models. [PDF]

Antibiotics (Basel)
Acunzo M, Zannella C, Giugliano R, Di Clemente L, Capasso C, Chianese A, Andriolo M, Donadio F, Esposito E, Monti A, Doti N, Fasciana TMA, Giammanco A, Galdiero M, Filippis A.   +14 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

In vitro models of the male reproductive system: applications for developmental and reproductive toxicology. [PDF]

Toxicol Sci
Hansen BC, Aryeh KS, Lindell LX, Lau GK, Nicholson TM, Faustman EM, Kelly EJ.   +6 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Adult Stem Cell-Derived Intestinal Organoids as In Vitro Models of High-Fat Diet-Related Intestinal Diseases. [PDF]

Biomolecules
Liu Y, Chen L, Liu Z, Jia D, Zhou Y, Tan J.   +5 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Development and Transformation of Veterinary Experimental In Vitro Models: From 2D Culture to 3D Organoids. [PDF]

Animals (Basel)
Hu X, Xie Y, Wang J, Zhang X, Wu R.
europepmc   +1 more source