Results 21 to 30 of about 115,798,289 (300)
Noninvasive molecular imaging of neuroinflammation [PDF]
, 2011 Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and
Jacobs, A.H. (Andreas) +15 more
core +1 more source
Site-Specific Radiolabeling of a Human PD-L1 Nanobody via Maleimide–Cysteine Chemistry
Pharmaceuticals, 2021 Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) and its ligand PD-L1 have proven to be efficient cancer therapies in a subset of patients. From all the patients with various cancer types, only 20% have a positive response. Being
Dora Mugoli Chigoho +8 more
doaj +1 more source
Nanoparticles for multimodal in vivo imaging in nanomedicine [PDF]
, 2014 Jaehong Key,1–3 James F Leary1–41Weldon School of Biomedical Engineering, 2Birck Nanotechnology Center, 3Bindley Bioscience Center, 4College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAAbstract: While nanoparticles are ...
Key, Jaehong +3 more
core +1 more source
Nature Methods, 2019 Developments in genetically encoded voltage indicators and imaging strategies enable the recording of multiple neurons with good signal-to-noise ratios in behaving mice.
openaire +2 more sources
EJNMMI Physics, 2022 Background In order to acquire accurate drug pharmacokinetic information, which is required for tissue dosimetry, micro-SPECT must be quantitative to allow for an accurate assessment of radioligand activity in the relevant tissue. This study investigates
Clarita Saldarriaga Vargas +4 more
doaj +1 more source
Cold Spring Harbor Protocols, 2010 INTRODUCTIONLight microscopy of tumors, as for other thick, scattering tissues such as the brain or the developing embryo, is limited by light penetration and optical access. because of these problems, epifluorescence and confocal microscopy are typically limited to the outer 50-100 μm of the accessible tumor tissue.
Edward, Brown +3 more
openaire +3 more sources
Video_2_In vivo Two-Photon Imaging of Anesthesia-Specific Alterations in Microglial Surveillance and Photodamage-Directed Motility in Mouse Cortex.AVI [PDF]
, 2019 Two-photon imaging of fluorescently labeled microglia in vivo provides a direct approach to measure motility of microglial processes as a readout of microglial function that is crucial in the context of neurodegenerative diseases, as well as to ...
Sun, Weilun +13 more
core +1 more source
Frontiers in Neuroimaging, 2023 IntroductionThe brainstem locus coeruleus (LC) influences a broad range of brain processes, including cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that consists of a local hyperintensity on specific Magnetic ...
Alexandre Berger +23 more
doaj +1 more source
In Vivo Validation of Electrocardiographic Imaging [PDF]
JACC: Clinical Electrophysiology, 2017 The purpose of this study was to evaluate the accuracy of noninvasive reconstructions of epicardial potentials, electrograms, activation and recovery isochrones, and beat origins by simultaneously performing electrocardiographic imaging (ECGI) and invasive epicardial electrography in intact animals.Noninvasive imaging of electrical potentials at the ...
Cluitmans, Matthijs J.M. +9 more
openaire +3 more sources
Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases
Pharmaceutics, 2019 Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities.
Janik Puttemans +3 more
doaj +1 more source