Results 1 to 10 of about 1,674,283 (217)

Refined in vivo model for bone regeneration: insights into scaffold architecture and porosity [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundThe architecture of bone substitute scaffolds—particularly pore size and organization—plays a crucial role in orchestrating immune responses, osteogenesis and angiogenesis. Yet, the mechanisms linking scaffold design to the temporal dynamics of
Laurine Marger, Mélanie Freudenreich, Mustapha Mekki, Daniel Manoil, Fabrice Marger, Sanae El Harane, Baptiste Charbonnier, Jérôme Charmet, Nicolo Brembilla, Olivier Preynat-Seauve, Stéphane Durual   +10 more
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A Brief Interpretation of CCAC Guide on Humane Endpoints of Animals: 2022 Edition

Shiyan dongwu yu bijiao yixue, 2022
The 2022 Canadian Council On Animal Care (CCAC) guidelines: Identification of Scientific Endpoints, Human Intervention Points, and Cumulative Endpoints (CCAC Guide) supplements existing laboratory animal humane endpoint theory according to the latest ...
LI Xiaying, WEI Yusheng, TIAN Yonglu, PANG Wanyong   +3 more
doaj   +1 more source

A rabbit model of ear otitis established using the Malassezia pachydermatis strain C23 from dogs [PDF]

Veterinary World, 2023
Background and Aim: Fungal infections are a growing problem for both humans and animals due to the emergence of pathogenic strains resistant to modern antifungal treatments.
Nadezhda Sachivkina, Arfenya Karamyan, Olesya Petrukhina, Olga Kuznetsova, Ekaterina Neborak, Alfia Ibragimova   +5 more
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A Comparative Analysis of CNAS Laboratory Animal Institutions Accreditation and AAALAC Certification

Shiyan dongwu yu bijiao yixue, 2022
China National Accreditation Service for Conformity Assessment (CNAS) laboratory animal institutions accreditation is an important system for the management of laboratory animals in China.
WU Xiaohuai, XIAO Qiaozhe, PANG Wanyong, BAI Yu, LI Yao, LU Xuancheng, FENG Tao   +6 more
doaj   +1 more source

Modeling Paratuberculosis in Laboratory Animals, Cells, or Tissues: A Focus on Their Applications for Pathogenesis, Diagnosis, Vaccines, and Therapy Studies

Animals, 2023
Paratuberculosis is a chronic granulomatous enteritis caused by Mycobacterium avium subsp. Paratuberculosis that affects a wide variety of domestic and wild animals.
Ana Jolly, Bárbara Fernández, Silvia Leonor Mundo, Natalia Elguezabal   +3 more
doaj   +1 more source

CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

Scientific Reports, 2021
Phenylketonuria (PKU) is an autosomal recessive inborn error of l-phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the enzyme phenylalanine hydroxylase (PAH), which is necessary for conversion of Phe to tyrosine (Tyr ...
Kuldeep Singh, Cathleen S. Cornell, Robert Jackson, Mostafa Kabiri, Michael Phipps, Mitul Desai, Robert Fogle, Xiaoyou Ying, Gulbenk Anarat-Cappillino, Sarah Geller, Jennifer Johnson, Errin Roberts, Katie Malley, Tim Devlin, Matthew DeRiso, Patricia Berthelette, Yao V. Zhang, Susan Ryan, Srinivas Rao, Beth L. Thurberg, Dinesh S. Bangari, Sirkka Kyostio-Moore   +21 more
doaj   +1 more source

Intestinal Transcytosis of a Protein Cargo and Nanoparticles Mediated by a Non-Toxic Form of Pseudomonas aeruginosa Exotoxin A

Pharmaceutics, 2021
The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route.
Ruiying Li, Floriane Laurent, Alistair Taverner, Julia Mackay, Paul A. De Bank, Randall J. Mrsny   +5 more
doaj   +1 more source

Murine SEC24D can substitute functionally for SEC24C during embryonic development

Scientific Reports, 2021
The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes encode four Sec24 paralogs (Sec24a-d), with two subfamilies based on sequence homology ...
Elizabeth J. Adams, Rami Khoriaty, Anna Kiseleva, Audrey C. A. Cleuren, Kärt Tomberg, Martijn A. van der Ent, Peter Gergics, Vi T. Tang, Guojing Zhu, Mark J. Hoenerhoff, K. Sue O’Shea, Thomas L. Saunders, David Ginsburg   +12 more
doaj   +1 more source

Targeted Propolis-Loaded Poly (Butyl) Cyanoacrylate Nanoparticles: An Alternative Drug Delivery Tool for the Treatment of Cryptococcal Meningitis

Frontiers in Pharmacology, 2021
In this study, we describe a nano-carrier system for propolis that is able to cross an in vitro model of the blood-brain barrier (BBB) and effectively reduce the virulence of Cryptococcus neoformans in animal models.
Patcharin Thammasit, Patcharin Thammasit, Patcharin Thammasit, Chayada Sitthidet Tharinjaroen, Chayada Sitthidet Tharinjaroen, Yingmanee Tragoolpua, Volker Rickerts, Radostina Georgieva, Radostina Georgieva, Hans Bäumler, Khajornsak Tragoolpua, Khajornsak Tragoolpua   +11 more
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Optimisation of the Chicken Chorioallantoic Membrane Assay in Uveal Melanoma Research

Pharmaceutics, 2021
The treatment of uveal melanoma and its metastases has not evolved sufficiently over the last decades in comparison to other tumour entities, posing a great challenge in the field of ocular oncology.
Ekaterina A. Sokolenko, Utta Berchner-Pfannschmidt, Saskia C. Ting, Kurt W. Schmid, Nikolaos E. Bechrakis, Berthold Seitz, Theodora Tsimpaki, Miriam Monika Kraemer, Miltiadis Fiorentzis   +8 more
doaj   +1 more source