Results 21 to 30 of about 1,674,283 (217)
Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
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Development of experimental models of reactivated toxoplasmosis [PDF]
Medicinski PodmladakToxoplasmosis is one of the most widespread zoonosis worldwide, since Toxoplasma gondii (T. gondii) is a ubiquitous obligate intracellular protozoan parasite that infects up to one third of the human population. Although infection is usually asymptomatic
Bauman Neda +2 more
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Frontiers in Microbiology, 2020 The chemotherapeutic options for methicillin-resistant Staphylococcus aureus (MRSA) infections are limited. Due to the multiple resistant MRSA, therapeutic failure has occurred frequently, even using antibiotics belonging to different categories in ...
Yang Yu +11 more
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Disease Models & Mechanisms, 2022 With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed.
Nils-Jørgen Knudsen Dal +9 more
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Tumor models in the investigation of oral cancer pathogenesis and treatment development
RUDN Journal of MedicineRelevance. Oral cancer is one of the most common cancers among neoplasms of the head and neck. Oral cancer is characterized by a poor prognosis, a lack of specific biomarkers and highly effective targeted treatment.
Maria S. Tretyakova +4 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
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Optimization of a closed rat tibial fracture model
Journal of Experimental Orthopaedics, 2018 Background The use of a closed fracture model has become the preferred model to study the fracture healing process, given that the periosteum and the soft tissue surrounding the fracture site play an important role in the fracture healing process.
Kareem Obayes Handool +6 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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MODERN METHODS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY MODELING IN VIVO
Вопросы современной педиатрии, 2014 Review describes modern approaches to the study of pathogenic mechanisms of perinatal hypoxic-ischemic brain injury. The classification of modeling methods hypoxic-ischemic brain injury in vivo reflects the basic approaches to disease modeling. Given the
A. V. Morgun +5 more
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