Results 171 to 180 of about 27,055 (211)

Metabolism and mutagenicity of acrylonitrile: An in vivo study

Environmental Mutagenesis, 1985
AbstractThe mutagenic activity present in urine of animals treated with acrylonitrile (ACN) is tentatively related to the excretion of three urinary metabolites: thiocyanate (SCN−), hydroxyethylmercapturic acid (OH‐MA), and cyanoethylmercapturic acid (CN‐MA).
M, Lambotte-Vandepaer, M, Duverger-van Bogaert, B, Rollmann   +2 more
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Cyclohexylamine mutagenicity: An in vivo evaluation utilizing fetal lambs

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Summary The in vivo effects of cyclohexylamine (CHA) upon the segregation apparatus and chromosome morphology of mitogenically capable lymphocytes obtained from the peripheral circulating blood tissue of living fetal lambs in utero were evaluated. CHA proved to be a clastogen in vivo .
J H, Turner, D L, Hutchinson
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In vivo mutagenic interaction of nitrite and ethylenethiourea

Experientia, 1975
N-Nitroso-Athylenthioharnstoff induziert Mutationen inSalmonella typhimurium. Diese Verbindung wird im Magen von Mausen aus Natriumnitrit und Athylenthioharnstoff gebildet; ihre Mutagenitat wird mit Hilfe des Mikrokerntests gezeigt.
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Mutagenic potential of temozolomide in bone marrow cells in vivo

Blood, 2006
Therapy-related myeloid leukemias (t-MLs) occur in as many as 5% to 10% of patients who are otherwise cured of a primary neoplasm with aggressive multimodal regimens. Many patients with t-MLs or therapy-related myelodysplastic syndrome (t-MDS) have previously received chemotherapeutic agents ...
Hartmut, Geiger, David, Schleimer, Kalpana J, Nattamai, Stefanie R, Dannenmann, Stella M, Davies, Brian D, Weiss   +5 more
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Possibilities of routine in vivo mutagenicity testing in mammals

Archiv f�r Toxikologie, 1971
In general, mutations have a negative effect on man. Considering the great number of substances inducing mutagenic effects in microorganisms and in cell cultures, the question arises whether these substances are a genetic risk for man, too. Final statements concerning this matter should be based on in vivo investigations which fully take into account ...
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Lack of Mutagenic Effects of Halothane in Mammals In Vivo

Anesthesiology, 1981
Rodents were exposed in vivo to various clinical doses of halothane to observe structural chromosome aberrations, micronuclei, sister chromatid exchanges (SCEs), dominant lethal mutations, and interferences with phases of the cell cycle. The frequency of chromosome aberrations in bone marrow cells was not increased after exposing Chinese hamsters to 1 ...
A, Basler, G, Röhrborn
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Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014
Hydroquinone (HQ) is used in skin bleaching agents, hair dyes, and finger nail treatments. Many skin-lightening cosmetics that contain HQ are currently marketed in Japan. Concerns have been expressed regarding health risks to the general population because the carcinogenicity of HQ was previously suggested in animal studies.
Mariko, Matsumoto, Shoji, Masumori, Mutsuko, Hirata-Koizumi, Atsushi, Ono, Masamitsu, Honma, Kazuhito, Yokoyama, Akihiko, Hirose   +6 more
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In vitro and in vivo assays of isopropanol for mutagenicity

Environmental and Molecular Mutagenesis, 1993
AbstractTo assess the mutagenic potential of isopropanol, an in vitro Chinese hamster ovary (CHO) cell/HGPRT gene mutation assay and a bone marrow micronucleus study in mice were conducted. In the CHO/HGPRT assay, concentration levels ranged from 0.5 to 5.0 mg/ml.
R W, Kapp, D J, Marino, T H, Gardiner, L W, Masten, R H, McKee, T R, Tyler, J L, Ivett, R R, Young   +7 more
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EPA use of in vivo germ cell mutagenicity data

Environmental and Molecular Mutagenesis, 1991
AbstractThe Toxic Substances Control Act (TSCA) provides the U.S. Environmental Protection Agency, Office of Toxic Substances (EPA, OTS) with the authority to regulate chemical use by requiring testing and use restrictions as appropriate to protect human health.
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Chemical mutagen testing on in vivo somatic mammalian cells

Agents and Actions, 1973
Possibilities and limitations in the use of in vivo cytogenetic tests on somatic cells are discussed. Special attention is focused on the problems raised by the relative insensivity of the available procedures. It is emphasized that in planning screening tests the accumulated experience from studies with known chromosome breaking chemicals must be ...
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