Results 181 to 190 of about 27,055 (211)

A mutagenic in vivo metabolite of sodium azide

Mutation Research/Environmental Mutagenesis and Related Subjects, 1978
Experimental evidence is presented for the presence of a mutagenic metabolite formed in vivo in barley embryos exposed to sodium azide. The mutagenic substance found in extracts after removal of free azide by acidification was partially purified by liquid column chromatography and eluted.
W.M. Owais, M.A. Zarowitz, R.A. Gunovich, A.L. Hodgdon, A. Kleinhofs, R.A. Nilan   +5 more
openaire   +1 more source

In Vivo Mutagenicity Testing of Arylboronic Acids and Esters

Environmental and Molecular Mutagenesis, 2019
Arylboronic acids and esters (referred to collectively as arylboronic compounds) are commonly used intermediates in the synthesis of pharmaceuticals but pose a challenge for chemical syntheses because they are often positive for bacterial mutagenicity in vitro.
Melisa J, Masuda-Herrera, Krista L, Dobo, Michelle O, Kenyon, Julia D, Kenny, Sheila M, Galloway, Patricia A, Escobar, M Vijayaraj, Reddy, Robert A, Jolly, Alejandra, Trejo-Martin, Caren, Brown, Marie, Mckeon, Megan, Young, Shannon, Bruce, Kamala, Pant, Aparajita, Dutta, Rohan, Kulkarni, Joel P, Bercu   +16 more
openaire   +2 more sources

Mutagenicity studies with 6-mercaptopurine: I. Cytogenetic activity in vivo

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973
Abstract Cytogenetic studies have been performed to determine the effect of 6-mercaptopurine (6-MP) on mammalian chromosomes in vivo . An elevated level of chromosome breakage is present in mouse bone marrow cells within 12 h after oral or parenteral dosing with 200 mg/kg.
H E, Holden, V A, Ray, M G, Wahrenburg, J D, Zelenski   +3 more
openaire   +2 more sources

In vitro and in vivo mutagenicity studies with airborne particulate extracts

Mutation Research/Genetic Toxicology, 1988
The contribution of nitro compounds to airborne particulate mutagenicity was studied with Salmonella typhimurium strains TA98, TA98NR, TA98/1,8DNP6. The results obtained indicate that nitropyrenes play a minor role in air particulate mutagenicity. Seasonal variations indicate a relatively greater contribution of nitro compounds to the mutagenicity of ...
R, Crebelli, S, Fuselli, A, Meneguz, G, Aquilina, L, Conti, P, Leopardi, A, Zijno, F, Baris, A, Carere   +8 more
openaire   +2 more sources

Mutagenicity of dimethylsulfoxide (DMSO): In vivo cytogenetics study in the rat

Teratogenesis, Carcinogenesis, and Mutagenesis, 1981
AbstractVarious concentrations (1%, 10%, 50%, and 100%) of laboratory grade dimethylsulfoxide (DMSO) were administered by intraperitoneal injection to male Sprague‐Dawley rats for five consecutive days. Femoral bone marrow cells were harvested 24 hours after the last injection and were analyzed for cytogenetic aberration frequencies including ...
R W, Kapp, B E, Eventoff
openaire   +2 more sources

Mutagenicity of Selected Chemicals in In Vivo Cytogenetic Assays

1981
There are a variety of test systems available for the analysis of chromosome aberrations following in vivo treatment. There are advantages and disadvantages to each, which means that the information obtained from any one test must be critically examined. Because of the variety of test systems employed, it is also impossible to provide a concise summary
R. J. Preston, I.-D. Adler, A. Léonard, M. F. Lyon   +3 more
openaire   +1 more source

[Mutagen-modifying effects of beta-carotene in vivo].

Genetika, 1997
A chromosome aberration test on bone marrow cells of C57B1/6 mice showed that beta-carotene (BC) applied by oral administration as a E160a food dye (30% oil suspension) at doses of 0.5, 5, and 50 mg/kg simultaneously with cyclophosphamide (CPA) and dioxidine (DN) injected intraperitoneally for a period of 24 h did not modify their clastogenic effects ...
A D, Durnev, L S, Tiurina, N V, Guseva, A V, Oreshchenko, S B, Seredenin   +4 more
openaire   +1 more source

In vivo mutagenicity of hexavalent chromium

Mutation Research/Environmental Mutagenesis and Related Subjects, 1995
S. Itoh, H. Shimada
openaire   +1 more source

Mutagenicity tests on epristeride in vitro and in vivo.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999
To evaluate the genetic effects of epristeride (Epr), a new prospective drug for treating benign prostatic hyperplasia.1) Assaying reverse mutation in histidine nutritional deficiency strain of Salmonella typhimurium 2) detecting chromosome aberrations in Chinese hamster lung cells (CHL); 3) micronucleus assays of mouse bone marrow; 4) counting sperm ...
X L, Wang, W J, Zhen, H Y, Wu, J, Feng, Z H, Tu   +4 more
openaire   +1 more source

Lack of In Vivo Mutagenicity of Acetamide in a 13-Week Comprehensive Toxicity Study Using F344 gpt Delta Rats

Toxicological Sciences, 2020
Yuji Ishii, Takehiko Nohmi, Makoto Shibutani   +2 more
exaly