Results 161 to 170 of about 27,055 (211)

Mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite

Environmental Mutagenesis, 1979
AbstractIn vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host‐mediated mutagenicity assay using Salmonella typhimurium as the detecting organism. It was possible to detect the product, N‐nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems.
W Z, Whong, N D, Speciner, G S, Edwards
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In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats

Archives of Toxicology, 2018
1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity of 1,4-dioxane remains unclear.
Min Gi, Masaki Fujioka, Anna Kakehashi, Takahiro Okuno, Kenichi Masumura, Takehiko Nohmi, Michiharu Matsumoto, Masako Omori, Hideki Wanibuchi, Shoji Fukushima   +9 more
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Mutagenic Effects of Hydroxylamine in vivo

Science, 1965
Hydroxylamine can induce any one of the four types of transition mutations in bacteriophage S13 if the mutagen is added directly to agar plates seeded with phage and bacterial indicators. The phage can also be mutated by treating the host cell with hydroxylamine before infecting it with phage.
I, TESSMAN, H, ISHIWA, S, KUMAR
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Mutagenicity of ipriflavone in vivo and in vitro

Food and Chemical Toxicology, 2012
Ipriflavone (7-isopropoxy-isoflavone) is a semisynthetic isoflavone derivative from daidzein and prescribed to prevent and treat osteoporosis in postmenopausal women. In the present study, ipriflavone was investigated with regard to their cytotoxic and mutagenic effects using the micronucleus assay (MN) in vivo on cells of bone marrow and peripheral ...
Luciano, Belcavello, Jean Carlos, Vencioneck Dutra, Josivany Valério, de Freitas, Ivar Pinheiro, Aranha, Maria, do Carmo Pimentel Batitucci   +4 more
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Mutagenic effects of ribavirin in vivo

Journal of Hepatology, 2005
Almost 200 million people worldwide are infected with hepatitis C virus (HCV). For these people treatment options are relatively limited, and they have recently evolved from IFN-a monotherapy to IFN-a/ribavirin to the present standard of PEG-IFN-a/ribavirin combination therapy.
Alan S. Perelson, Ruy M. Ribeiro
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In vivo mutagenicity studies with iodinated glycerol azeo

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1997
Previous studies have shown that iodinated glycerol azeo is positive in a number of in vitro mutagenicity assays including the Ames assay (TA100; TA1535), mouse lymphoma assay, Chinese hamster ovary (cytogenetic) assay and in one in vivo study, the sex-linked-recessive-lethal assay in Drosophila.
J H, McGee, J R, San Sebastian, R D, Sofia   +2 more
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In vivo cytogenetic effects of cooked food mutagens

Mutation Research/Genetic Toxicology, 1989
Using a variety of in vivo cytogenetic endpoints, we have investigated the effects of several compounds formed during the cooking of meat. C57Bl/6 mice were used to test for an increase in the frequency of sister-chromatid exchanges (SCEs), chromosomal aberrations, and micronucleated erythrocytes by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
J D, Tucker, A V, Carrano, N A, Allen, M L, Christensen, M G, Knize, C L, Strout, J S, Felton   +6 more
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Cycasin: Detection of Associated Mutagenic Activity in vivo

Science, 1969
Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the host-mediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the ...
M G, Gabridge, A, Denunzio, M S, Legator
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Mutagenicity tests with astemizole in vitro and in vivo

Archives of Toxicology, 1982
Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice.
P, Vanparys, L, Fabry, A, Léonard, R, Marsboom   +3 more
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Mutagenicity tests with domperidone in vitro and in vivo

Toxicology Letters, 1982
Abstract Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes.
P, Vanparys, L, Fabry, A, Leonard, R, Marsboom   +3 more
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