Results 141 to 150 of about 117,900,808 (282)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, Volume 13, Issue 59, 23 October 2026.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria, Amy Gelmi, Peter C. Sherrell, Stefan Di Medio, Nhiem Tran, Kate Fox   +5 more
wiley   +1 more source

Rational Design of N‐2‐(7‐Chloroquinolin‐4‐ylamino)ethyl Amides Active Against Chloroquine‐Resistant Plasmodium falciparum

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
Of 22 chloroquine (CQ) analogs, 16 showed IC503D7 values of 27–555 nM; their activity against the CQ‐resistant K1 strain and in silico/vitro hepatotoxicity were evaluated. Benzamides with chlorine and nitro groups were most active, showing IC50K1 and RI values lower than CQ and cytotoxic concentrations well above inhibitory concentrations.
Everton P. Silva, Camila S. Barbosa, Anna C. C. Aguiar, Ramon G. Oliveira, Thiago A. M. Brito, Marcelo F. R. Silva, Helivaldo D. S. Souza, Petrônio F. Athayde‐Filho, Gabriela F. Fiss   +8 more
wiley   +1 more source

Integrated Phylogenetic, Phytochemical, and In Silico Evaluation of Equisetum diffusum D. Don. Ethanolic Extract for Bioactivity

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ABSTRACT This study investigated the antibacterial and antioxidant potential of Equisetum diffusum D. Don. using in vitro assays, molecular docking, GC‐MS, HPLC, phytochemical screening, ADME, toxicity, and phylogenetic analyses. Phytochemical screening confirmed the presence of alkaloids, flavonoids, phenols, saponins, and fatty acids in the extracts.
Nasir Assad, Muhammad Naeem‐ul‐Hassan, Muhammad Fayyaz ur Rehman, Yasir Assad, Hansa Gul, Marzia Batool Laila, Muhammad Nauman Khan, Zahida Nasreen, Muhammad Adnan, Alevcan Kaplan, Sezai Ercişli   +10 more
wiley   +1 more source

Peumus boldus: Revealing the Pharmaceutical Potential of the Chilean Forest

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
P. boldus emerge as a promising yet underexplored source of bioactive compounds. Current evidence highlights antioxidant, anti‐inflammatory, antimicrobial, and cytoprotective activities associated with their unique phytochemical profile. This review integrates chemical composition, biological properties, proposed molecular mechanisms, and safety ...
Marta Rodríguez‐Ceballos, Valentina Jara, Sofía Díaz‐Cornejo, Valentina Morales, Rómulo Santelices‐Moya, Miguel Aguilera, Cristian Atala, María Carolina Otero, Felipe Gordillo‐Fuenzalida   +8 more
wiley   +1 more source

Phytochemical Fingerprinting of Sanchezia nobilis Hook. F. Leaf Extract and Evaluation of Anxiolytic, Cytotoxic, and Antioxidant Activities In Vivo, In Vitro, and In Silico

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
GC‐MS fingerprinting demonstrated that ethanolic leaf extract of Sanchezia nobilis (SNE) many phytochemicals out of which aniline and isoquinoline showed potential binding affinity to alpha1GABAA receptor responsible for anxiolytic effects. In vitro studies confirmed antioxidant effects of SNE.
Progga Paramita Paul, Musfiqur Rahman Sakib, Pritam Kundu, Dabashis Chakraborty, Tasnim Fatema, Shahriar Hossen, Ahsan Abid, Trina Mitra, Manik Chandra Shill, Utpal Kumar Karmakar   +9 more
wiley   +1 more source

Biological Activities and Phytochemical Composition of Arum rupicola var. rupicola: An In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Phytochemical profiling and in vitro bioactivity evaluation of Arum rupicola var. rupicola extracts revealed rutin as the dominant phenolic compound in aerial parts, demonstrating high binding affinities against cancer‐related and antimicrobial target proteins via molecular docking. The most significant finding in the cytotoxicity study was observed in
Selim Can Kamalak, Ela Nur Şimşek Sezer, Erdoğan Güneş   +2 more
wiley   +1 more source

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

Anti‐Inflammatory Activity of Cotula cinerea Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Cotula cinerea essential oil was chemically profiled and evaluated in an exploratory in vivo model with histological assessment, while computational analyses generated hypotheses for interactions of selected constituents with COX‐2 and BSA. The predictive findings require direct experimental validation. ABSTRACT The anti‐inflammatory activity of Cotula
Habiba Haddad, Mohammed Larbi Benamor, Yahia Bekkar, Ouafa Boudebia, Salah Neghmouche Nacer, Elhafnaoui Lanez, Aicha Adaika, Taher M. Abdelhameed, Lazhar Bechki, Touhami Lanez, Stefania Garzoli   +10 more
wiley   +1 more source