Systematic CRISPR-mediated functional fine mapping of inborn errors of immunity causal genes in primary human T cells and hematopoietic stem cells: To predict all IL2RG mutations that cause X-SCID 4748 [PDF]
Yu Rong +7 more
openalex +1 more source
ABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Ana Carolina Silva Guimarães +9 more
wiley +1 more source
Autoimmune cytopenias in inborn errors of immunity: associations with monogenic mutations and immunologic parameters. [PDF]
Sağun F +6 more
europepmc +1 more source
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li +5 more
wiley +1 more source
Mapping the landscape of autoimmunity and autoinflammation in inborn errors of immunity: broad distribution with distinct clustering patterns. [PDF]
Tahiat A +30 more
europepmc +1 more source
The Global Burden of Cholesteatoma: A Systematic Review and Meta‐analysis
Abstract Objective This systematic review and meta‐analysis sought to estimate the global and World Health Organization (WHO) regional prevalence and burden of cholesteatoma. Data Sources PubMed, APA PsycINFO, the Cochrane Library, Embase, and WHO International Clinical Trials Registry Platform (ICTRP) from 2010 to 2025.
Herbert Melariri +21 more
wiley +1 more source
Rheumatologic and Autoimmune Features of Inborn Errors of Immunity: Implications for Diagnosis and Management. [PDF]
Tobin JM, Cooper MA.
europepmc +1 more source
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Masoud Foroutan +2 more
wiley +1 more source
First report from the Czech national registry of inborn errors of immunity (2012-2025). [PDF]
Chovancova Z +26 more
europepmc +1 more source

