Results 11 to 20 of about 16,445 (315)
Inborn Errors of Immunity and Cancer [PDF]
Biology, 2021 Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders characterized by a defect in the function of at least one, and often more, components of the immune system.
Alessandra Tiri +7 more
doaj +7 more sources
Inborn errors of immunity with eosinophilia
Allergology International, 2021 Monogenic diseases of the immune system, also known as inborn errors of immunity (IEIs), are caused by single-gene mutations and result in immune deficiency and dysregulation.
Keisuke Okamoto, Tomohiro Morio
doaj +4 more sources
Granulomatous inflammation in inborn errors of immunity [PDF]
Frontiers in Pediatrics, 2023 Granulomas have been defined as inflammatory infiltrates formed by recruitment of macrophages and T cells. The three-dimensional spherical structure typically consists of a central core of tissue resident macrophages which may merge into multinucleated ...
Keith A. Sacco +3 more
doaj +6 more sources
Neuroinflammation Associated With Inborn Errors of Immunity [PDF]
Frontiers in Immunology, 2022 The advent of high-throughput sequencing has facilitated genotype-phenotype correlations in congenital diseases. This has provided molecular diagnosis and benefited patient management but has also revealed substantial phenotypic heterogeneity.
Hannes Lindahl +4 more
doaj +8 more sources
Endocrinopathies in Inborn Errors of Immunity [PDF]
Frontiers in Immunology, 2021 Inborn errors of immunity (IEI), caused by hereditary or genetic defects, are a group of more than 400 disorders, in which the immune system, including lymphocytes, neutrophils, macrophages, and complements, does not function properly.
Kei Takasawa +3 more
doaj +3 more sources
International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity [PDF]
, 2017 Beginning in 1970, a committee was constituted under the auspices of the World Health Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, the International Union of Immunological Societies (IUIS) took the remit of this committee.
Al-Herz, W +19 more
core +6 more sources
The Ever-Increasing Array of Novel Inborn Errors of Immunity : an Interim Update by the IUIS Committee [PDF]
, 2021 The most recent updated classification of inborn errors of immunity/primary immunodeficiencies, compiled by the International Union of Immunological Societies Expert Committee, was published in January 2020.
Al-Herz, Waleed +17 more
core +4 more sources
Nature and nurture: understanding phenotypic variation in inborn errors of immunity [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 The overall disease burden of pediatric infection is high, with widely varying clinical outcomes including death. Among the most vulnerable children, those with inborn errors of immunity, reduced penetrance and variable expressivity are common but poorly
Morgan Similuk, Taco Kuijpers
doaj +3 more sources
Dendritic cells in inborn errors of immunity [PDF]
Frontiers in Immunology, 2023 Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They play critical role in homeostasis, inflammation, and autoimmunity.
Sudhir Gupta, Anshu Agrawal
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Inborn Errors of Immunity: how to diagnose them?
Jornal de Pediatria, 2021 Objectives: Inborn Errors of Immunity are characterized by infectious conditions and manifestations of immune dysregulation. The diversity of clinical phenotypes can make it difficult to direct the laboratory investigation.
Anete Sevciovic Grumach +1 more
doaj +2 more sources