oqxAB-Positive IncHI2 Plasmid pHXY0908 Increase Salmonella enterica Serotype Typhimurium Strains Tolerance to Ciprofloxacin. [PDF]
Front Cell Infect Microbiol, 2019 Salmonella enterica serotype Typhimurium is a major global food-borne pathogen and causes life-threatening infections. Although the resistance mechanisms to fluoroquinolones in S. Typhimurium had been well-defined, tolerance to fluoroquinolones and the associated mechanism for this are obscure.
Lian X +7 more
europepmc +5 more sources
Longitudinal Molecular Epidemiology and Genomic Surveillance of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in the Gut of Healthy Individuals in China. [PDF]
MedComm (2020)Using 16,040 stool samples from healthy individuals across 30 Chinese provinces (2016–2024), we performed longitudinal genomic surveillance of carbapenem‑resistant Klebsiella pneumoniae (CRKP) colonizing the gut. We reveal rising community CRKP prevalence, especially in southern China, a shift from blaKPC‐2 to plasmid‑borne blaNDM‐5 on IncHI2/IncHI2A ...
Yan Z +11 more
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Plasmid double locus sequence typing for IncHI2 plasmids, a subtyping scheme for the characterization of IncHI2 plasmids carrying extended-spectrum β-lactamase and quinolone resistance genes [PDF]
Journal of Antimicrobial Chemotherapy, 2010 IncHI2 plasmids are frequently encountered in clinical enterobacterial strains associated with the dissemination of relevant antimicrobial resistance genes. These plasmids are usually >250 kb, and technical difficulties can impair plasmid DNA purification and comparison by restriction fragment length polymorphism. We analysed the available IncHI2 whole
Garcia-Fernández A., Carattoli A.
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Potential spread of mcr-9-carrying IncHI2 plasmids in Enterobacter hormaechei in Vietnam
Journal of Global Antimicrobial Resistance, 2021 Mobile colistin resistance (mcr) genes are widely distributed around the world. To date, ten major variants of mcr genes are known (mcr-1 to mcr-10). However, only a few instances of Enterobacterales isolates harbouring mcr genes other than mcr-1 have been reported in Vietnam.
Van Thi Thu Ha +7 more
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Spread of oqxAB in Salmonella enterica serotype Typhimurium predominantly by IncHI2 plasmids [PDF]
Journal of Antimicrobial Chemotherapy, 2013 To investigate the prevalence and genetic environment of the multiresistance gene oqxAB in Salmonella enterica serotype Typhimurium isolated from food-producing animals.In this study, 63 Salmonella enterica serotype Typhimurium isolates were analysed for the presence of plasmid-mediated quinolone resistance determinants and mutations in the quinolone ...
Liang, Li +10 more
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PLoS ONE, 2022 The bacterium Serratia marcescens can cause opportunistic infections in humans and in animals. In veterinary settings, the diversity, reservoirs and modes of transmission of this pathogen are poorly understood.
Joanne L. Allen +4 more
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Mapping studies and genetic analysis of transfer genes of the multi-resistant IncHI2 plasmid, R478 [PDF]
FEMS Microbiology Letters, 1999 A bank of transfer-defective Tn7 insertion mutants of the multi-resistant IncHI2 megaplasmid, R478, was generated. Complementation analysis of these mutations identified a large 144-kb transfer-associated region of R478. A 6.8-kb segment from the transfer region was sequenced.
D T, Page, K F, Whelan, E, Colleran
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Frontiers in Microbiology, 2022 IncHI2 plasmids, possessing high flexibility and genetic plasticity, play a vital role in the acquisition and transmission of resistance determinants. Polymorphic mobile genetic elements (MGEs) generated by a chromosomally integrated IncHI2 plasmid in an
Man-Xia Chang +9 more
doaj +1 more source
Acquisition and diffusion of bla CTX-M-9 gene by R478-IncHI2 derivative plasmids. [PDF]
FEMS microbiology letters, 2007 Escherichia coli and Salmonella enterica isolates carrying the bla(CTX-M-9) gene located on plasmids prevailed at the Hospital de la Santa Creu i Sant Pau, Barcelona, Spain in the 1996-1999 period. The bla(CTX-M-9)-carrying plasmids showed a great variability in size, suggesting the mobilization of the gene among different plasmid scaffolds. The aim of
García A +6 more
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Evolution of IncHI2 plasmids via acquisition of transposons carrying antibiotic resistance determinants [PDF]
Journal of Antimicrobial Chemotherapy, 2012 To investigate the relationships between IncHI2 plasmids conferring resistance to antibiotics isolated in Australia and those from other countries.PCR, restriction digestion, cloning and DNA sequencing were used to characterize transposons and determine their location in IncHI2 plasmids recovered from Salmonella enterica isolates from Australian ...
Amy K, Cain, Ruth M, Hall
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