Results 1 to 10 of about 5,841,978 (243)

Decoding the origins, spread, and global risks of mcr-9 geneResearch in context [PDF]

EBioMedicine
Summary: Background: The global spread of the plasmid-mediated mcr (mobilized colistin resistance) gene family presents a significant threat to the efficacy of colistin, a last-line defense against numerous Gram-negative pathogens.
Kaiwen Song, Longyang Jin, Meng Cai, Qi Wang, Xingyu Wu, Shuyi Wang, Shijun Sun, Ruobing Wang, Fengning Chen, Hui Wang   +9 more
doaj   +6 more sources

Development of a Novel mcr-6 to mcr-9 Multiplex PCR and Assessment of mcr-1 to mcr-9 Occurrence in Colistin-Resistant Salmonella enterica Isolates From Environment, Feed, Animals and Food (2011–2018) in Germany [PDF]

Frontiers in Microbiology, 2020
The polymyxin antibiotic colistin has been used in decades for treatment and prevention of infectious diseases in livestock. Nowadays, it is even considered as last-line treatment option for severe human infections caused by multidrug- and carbapenem ...
Carlus Deneke, Burkhard Malorny, Jens André Hammerl   +2 more
exaly   +6 more sources

Epidemiology and Molecular Characteristics of mcr-9 in Citrobacter spp. from Healthy Individuals and Patients in China [PDF]

Microbiology Spectrum, 2022
With the globally prevailing carbapenemase-producing (CP) Citrobacter spp., polymyxin antibiotics have been reconsidered as one of the last-resort treatment options.
Xiaoyang Ju, Siheng Wang, Xuemei Yang, Weihua Han, Chang Cai, Yuchen Wu, Congcong Liu, Jiao Qian, Xiaofei Zhao, Xiang Qian, Qiaoling Sun, Rong Zhang, Gongxiang Chen   +12 more
doaj   +4 more sources

Genomic Characterization of ESBL- and Carbapenemase-Positive Enterobacteriaceae Co-harboring mcr-9 in Japan [PDF]

Frontiers in Microbiology, 2021
Worldwide spread of Enterobacteriaceae resistant to colistin, a polypeptide antibacterial drug for last-resort treatment of carbapenemase-producing Enterobacteriaceae (CPE) infections, is concerning.
Akihiro Nakamura, Tatsuya Nakamura, Makoto Niki, Tomokazu Kuchibiro, Isao Nishi, Masaru Komatsu   +5 more
doaj   +5 more sources

Emergence of Neonatal Sepsis Caused by MCR-9- and NDM-1-Co-Producing Enterobacter hormaechei in China [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Mobile colistin resistance (mcr) genes represent an emerging threat to public health. Reports on the prevalence, antimicrobial profiles, and clonality of MCR-9-producing Enterobacter cloacae complex (ECC) isolates on a national scale in China are limited.
Chunlei Chen, Hao Xu, Hao Xu, Ruishan Liu, Ruishan Liu, Xinjun Hu, Jianfeng Han, Lingjiao Wu, Hao Fu, Beiwen Zheng, Beiwen Zheng, Beiwen Zheng, Yonghong Xiao, Yonghong Xiao, Yonghong Xiao   +14 more
doaj   +4 more sources

Clinical and Genomic Epidemiology of mcr-9-Carrying Carbapenem-Resistant Enterobacterales Isolates in Metropolitan Atlanta, 2012 to 2017 [PDF]

Microbiology Spectrum, 2022
Colistin is a last-resort antibiotic for multidrug-resistant Gram-negative infections. Recently, the ninth allele of the mobile colistin resistance (mcr) gene family, designated mcr-9, was reported.
Ahmed Babiker, Chris Bower, Joseph D. Lutgring, Robert A. Petit, Jessica Howard-Anderson, Uzma Ansari, Gillian McAllister, Michelle Adamczyk, Erin Breaker, Sarah W. Satola, Jesse T. Jacob, Michael H. Woodworth   +11 more
doaj   +4 more sources

Frequent convergence of mcr-9 and carbapenemase genes in Enterobacter cloacae complex driven by epidemic plasmids and host incompatibility [PDF]

Emerging Microbes and Infections, 2022
Convergence of mcr and carbapenemase genes has been sporadically detected in Enterobacter cloacae complex (ECC) with an upward trend. However, the state of the epidemic and underlying mechanism of such convergence has been poorly understood.
Tingting Xu, Chun-Xu Xue, Yuxin Chen, Junxi Huang, Weiyuan Wu, Yuemei Lu, Qiuhui Huang, Dandan Chen, Kai Zhou   +8 more
doaj   +4 more sources

Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand [PDF]

Scientific Reports
The surge in mobile colistin-resistant genes (mcr) has become an increasing public health concern, especially in carbapenem-resistant Enterobacterales (CRE).
Rujirat Hatrongjit, Thidathip Wongsurawat, Piroon Jenjaroenpun, Peechanika Chopjitt, Parichart Boueroy, Yukihiro Akeda, Kazuhisa Okada, Tetsuya Iida, Shigeyuki Hamada, Anusak Kerdsin   +9 more
doaj   +3 more sources

Emergence of colistin-resistant Enterobacter cloacae and Raoultella ornithinolytica carrying the phosphoethanolamine transferase gene, mcr-9, derived from vegetables in Japan [PDF]

Microbiology Spectrum, 2023
Colistin, a last-line antimicrobial agent, is recommended for the treatment of severe infections caused by multidrug-resistant (MDR) microorganisms.
Christian Xedzro, Toshi Shimamoto, Liansheng Yu, Hui Zuo, Yo Sugawara, Motoyuki Sugai, Tadashi Shimamoto   +6 more
doaj   +2 more sources

Adaptive colistin resistance dynamics in mcr-9-positive and -negative Enterobacterales following low-level colistin exposure [PDF]

Microbiology Spectrum
The mcr-9 gene has been reported across different sources and was recognized as a potential contributor to increased minimum inhibitory concentrations after colistin exposure. This study aimed to determine the prevalence of intestinal carriage of the mcr-
Eva Smelikova, Marie Brajerova, Jan Tkadlec, Pavel Drevinek, Marcela Krutova   +4 more
doaj   +2 more sources