Results 21 to 30 of about 130,174 (166)

Identification of a novel lineage of plasmids within phylogenetically diverse subclades of IncHI2-ST1 plasmids

Plasmid, 2019
© 2019 Elsevier Inc. IncHI2-ST1 plasmids play an important role in co-mobilizing genes conferring resistance to critically important antibiotics and heavy metals. Here we present the identification and analysis of IncHI2-ST1 plasmid pSPRC-Echo1, isolated
Djordjevic, SP, Fourment, M, Gottlieb, T, Merlino, J, DeMaere, MZ, Roy Chowdhury, P, Monahan, L, Darling, AE   +7 more
core   +3 more sources

Fitness Advantage of mcr-1–Bearing IncI2 and IncX4 Plasmids in Vitro

Frontiers in Microbiology, 2018
The objective of this study was to assess the impact of diverse plasmids bearing colistin resistance gene mcr-1 on host fitness. Forty-seven commensal E.
Renjie Wu, Ling-xian Yi, Lin-feng Yu, Jing Wang, Yiyun Liu, Xiaojie Chen, Luchao Lv, Jun Yang, Jian-Hua Liu   +8 more
doaj   +2 more sources

Complete Genome Sequence of a Colistin-Resistant Escherichia coli Strain Harboring mcr-1 on an IncHI2 Plasmid in the United States. [PDF]

Genome Announc, 2017
We report here the incidental detection and complete genome sequence of a urinary Escherichia coli strain harboring mcr-1 and resistant to colistin in a New York patient returning from Portugal in 2016.
Gilrane VL, Lobo S, Huang W, Zhuge J, Yin C, Chen D, Alvarez KJ, Budhai A, Nadelman I, Dimitrova N, Fallon JT, Wang G.   +11 more
europepmc   +4 more sources

Characterization of two autoreplicative regions of the inchi2 plasmid r478: rephi2a and rephi1a(r478)

Microbiology (Reading, England), 2001
Plasmids of the incompatibility groups HI and HII (IncH plasmids) generally confer multiple antibiotic resistances upon their host pathogenic strain.
Whelan, Kenneth F., Page, David T., Colleran, Emer   +2 more
core   +3 more sources

Transmissible ST3-IncHI2 Plasmids Are Predominant Carriers of Diverse Complex IS26-Class 1 Integron Arrangements in Multidrug-Resistant Salmonella [PDF]

Frontiers in Microbiology, 2018
Diverse mobile genetic elements (MGEs) including plasmids, insertion sequences, and integrons play an important role in the occurrence and spread of multidrug resistance (MDR) in bacteria.
Hang Zhao, Wenyao Chen, Xuebin Xu, Xiujuan Zhou, Chunlei Shi   +4 more
doaj   +2 more sources

Co-localization of carbapenem (blaOXA-162) and colistin (mcr-1) resistance genes on a transferable IncHI2 plasmid in Escherichia coli of chicken origin. [PDF]

J Antimicrob Chemother, 2021
Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective.
Bortolaia V, Ronco T, Romascu L, Nicorescu I, Milita NM, Vaduva AM, Leekitcharoenphon P, Kjeldgaard JS, Hansen IM, Svendsen CA, Mordhorst H, Guerra B, Beloeil PA, Hoffmann M, Hendriksen RS.   +14 more
europepmc   +2 more sources

Investigation of VIM-1-producing Enterobacter spp. across Switzerland: clonal dissemination and plasmid transmission [PDF]

Antimicrobial Agents and Chemotherapy
Carbapenemase-producing Enterobacterales (CPE) are a major public health concern. Within the Enterobacter cloacae complex (ECC), the blaVIM-1 carbapenemase gene is frequently plasmid-borne, enabling inter-clonal and inter-species spread that complicates ...
Helena M. B. Seth-Smith, Mariella Greutmann, Jacqueline Findlay, Christiane Beckmann, Livia Berlinger, Silvio D. Brugger, Riccarda Capaul, Gilbert Greub, Eva Gruner, Peter M. Keller, Oliver Nolte, Tim Roloff, Sarah Tschudin-Sutter, Walter Zingg, Patrice Nordmann, Laurent Poirel, Adrian Egli   +16 more
doaj   +2 more sources

Complete Sequences of Multiple-Drug Resistant IncHI2 ST3 Plasmids in Escherichia coli of Porcine Origin in Australia [PDF]

Frontiers in Sustainable Food Systems, 2019
IncHI2 ST3 plasmids are known carriers of multiple antimicrobial resistance genes. Complete plasmid sequences from multiple drug resistant Escherichia coli circulating in Australian swine is however limited.
Ethan R. Wyrsch, Cameron J. Reid, Matthew Z. DeMaere, Michael Y. Liu, Toni A. Chapman, Piklu Roy Chowdhury, Piklu Roy Chowdhury, Steven P. Djordjevic   +7 more
doaj   +2 more sources

One Health at Risk: Plasmid-Mediated Spread of mcr-1 Across Clinical, Agricultural, and Environmental Ecosystems

Antibiotics
The global dissemination of plasmid-mediated mcr genes, which confer resistance to the last-resort antibiotic colistin, represents a critical public health challenge driven by the interplay of clinical, agricultural, and environmental factors.
Abdelaziz Touati, Nasir Adam Ibrahim, Assia Mairi, Hassina Kirat, Nosiba S. Basher, Takfarinas Idres   +5 more
doaj   +2 more sources

Emergence of a novel hybrid mcr-1-bearing plasmid in an NDM-7-producing ST167 Escherichia coli strain of clinical origin

Frontiers in Microbiology, 2022
Colistin is considered as an antibiotic of ‘last resort’ for the treatment of lethal infections caused by carbapenem-resistant Enterobacterales (CRE), dissemination of plasmid-borne colistin resistance gene mcr-1, particularly into CRE, resulting in the ...
Shuang Xia, Wei Wang, Jing Cheng, Jing Cheng, Tingting Zhang, Tingting Zhang, Ziwei Xia, Ziwei Xia, Xiaoyu Zhao, Xiaoyu Zhao, Yungang Han, Yonghong Li, Yonghong Li, Xiufang Shi, Xiufang Shi, Shangshang Qin, Shangshang Qin   +16 more
doaj   +1 more source