Results 121 to 130 of about 143,348 (263)

From Inclusion Complexes to Innovative Therapies: Cyclodextrins and Their Pharmaceutical Applications. [PDF]

Pharmaceutics
Trasca DM, Pirscoveanu DFV, Varut RM, Pluta ID, Stoica GA.   +4 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inclusion complexes of amlodipine besylate and cyclodextrins

Open Chemistry, 2010
Kapor Agneš, Nikolić Vesna, Nikolić Ljubiša, Stanković Mihajlo, Cakić Milorad, Stanojević Ljiljana, Ilić Dušica   +6 more
doaj   +1 more source

From Inclusion Complexes to Metabolic Signaling: The Emerging Role of γ-Cyclodextrin in Gut Microbiota and Metabolic Regulation. [PDF]

Molecules
Vasilica PDF, Dorin PI, Rodica D, Vladulescu C, Trasca DM, Varut RM, Kamal A, Stoica M, Pura G, Popa R, Radulescu V, Stoica GA.   +11 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Computational Investigation of 4‑Nitrophenol Inclusion Complexes with α‑, β‑, and γ‑Cyclodextrins. [PDF]

ACS Omega
Vendrame LFO, Tonel MZ, da Rocha JAP, Zanella I, Rhoden CRB, Fagan SB.   +5 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Baicalein-Cyclodextrin Inclusion Complexes Nasal Thermosensitive Hydrogel: Bioavailability Improvement and Pharmacokinetic Evaluation in Rats. [PDF]

Pharmaceuticals (Basel)
Ji X, Wei X, Guo Z, Li Z, Li Y, Yang R, Jin Q.   +6 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Characterization, antifungal potential, cytocompatibility, and regenerative potential of mucoadhesive gel containing antifungal-β-cyclodextrin inclusion complexes. [PDF]

J Prosthodont
Sugio CYC, Garcia AAMN, Soares DG, Cassiano FB, de Mattos MA, Soares S, Ferrari PC, Fernandes MH, Urban VM, Neppelenbroek KH.   +9 more
europepmc   +1 more source