Results 71 to 80 of about 1,672 (143)

NDM-5-Producing Escherichia coli Co-Harboring mcr-1 Gene in Companion Animals in China

Animals, 2022
Carbapenem and colistin are important antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. Here, we isolated the blaNDM-5-harboring Escherichia coli in companion animals in healthy or diseased companion ...
Xu Kuang, Runshi Yang, Xinqing Ye, Jian Sun, Xiaoping Liao, Yahong Liu, Yang Yu   +6 more
doaj   +1 more source

Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs [PDF]

, 2017
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs ...
Ding, Youfa, Feng, Youjun, Hassan, Bachar, Li, Jun, Li, Xing-Ping, Lin, Jingxia, Sun, Jian, Wang, Qingjing   +7 more
core   +2 more sources

Genomic Features of MCR-1 and Extended-Spectrum β-Lactamase-Producing Enterobacterales from Retail Raw Chicken in Egypt. [PDF]

, 2021
Colistin is considered as a last resort agent for treatment of severe infections caused by carbapenem-resistant Enterobacterales (CRE). Recently, plasmid-mediated colistin resistance genes (mcr type) have been reported, mainly corresponding to mcr-1 ...
Abdelfattah Maky, M., Korashe Dandrawy, M., Nordmann, P., Ortiz de la Rosa, J.M., Poirel, L., Sadek, M.   +5 more
core   +1 more source

Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Carbapenemase‐producing Enterobacterales (CPE) have been reported in the food chain in 14 out of 30 EU/EFTA countries. Commonly reported genes are blaVIM‐1, blaOXA‐48 and blaOXA‐181, followed by blaNDM‐5 and blaIMI‐1. Escherichia coli, target of most of the studies, Enterobacter cloacae complex, Klebsiella pneumoniae complex and Salmonella ...
EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), Ana Allende, Avelino Álvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Fernando Pérez‐Rodríguez, Panagiotis Skandamis, Elisabetta Suffredini, Hector Argüello, Johan Bengtsson‐Palme, Alessandra Carattoli, Anke Kohlenberg, Dominique L. Monnet, Laurent Poirel, Beatriz Guerra, Raquel García‐Fierro, Ernesto Liébana, Sonagnon Martin Goudjihounde, Núria Ferrer‐Bustins, Hanne Rabbås, Luisa Peixe   +28 more
wiley   +1 more source

Genomic Characterization of Two Escherichia fergusonii Isolates Harboring mcr-1 Gene From Farm Environment

Frontiers in Cellular and Infection Microbiology, 2022
The prevalence and transmission of mobile colistin resistance (mcr) genes have led to a severe threat to humans and animals. Escherichia fergusonii is an emerging pathogen which is closely related to a variety of diseases.
Ruishan Liu, Ruishan Liu, Hao Xu, Xiaobing Guo, Shuxiu Liu, Jie Qiao, Haoyu Ge, Beiwen Zheng, Jianjun Gou   +8 more
doaj   +1 more source

DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr‐carrying Bacteria Through a Negative Feedback Regulatory Mechanism

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This work demonstrates that DNA polymerase IV dinB favors the adaptive fitness of mcr‐carrying bacteria via a negative feedback regulatory mechanism. Specifically, the elevation of ROS production by intact mcr activates dinB, which in turn represses the mcr expression, maintaining a balance between colistin resistance and bacterial fitness.
Haijie Zhang, Xia Xiao, Chenlong Wang, Yurong Zhao, Bo Chen, Xinyuan Ji, Lina Gu, Jie Wang, Zhiqiang Wang, Yuan Liu   +9 more
wiley   +1 more source

Mutational change of CTX‐M‐15 to CTX‐M‐127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient

MicrobiologyOpen, Volume 8, Issue 12, December 2019., 2019
In this study, we investigated the genetics behind mecillinam resistance which occurred in an extended‐spectrum β‐lactamase‐producing Escherichia coli during pivmecillinam treatment of a patient. The genomic comparison of the two isolates points toward a mutational change of blaCTX‐M‐15 into blaCTX‐M‐127 along with a serotype shift from rough to full ...
Karen Leth Nielsen, Katrine Hartung Hansen, Jesper Boye Nielsen, Jenny Dahl Knudsen, Kristian Schønning, Niels Frimodt‐Møller, Frederik Boëtius Hertz, Filip Jansåker   +7 more
wiley   +1 more source

Rapid Increase in the IS26-Mediated cfr Gene in E. coli Isolates with IncP and IncX4 Plasmids and Co-Existing cfr and mcr-1 Genes in a Swine Farm

Pathogens, 2021
This paper aimed to investigate the molecular epidemiological features of the cfr gene in E. coli isolates in a typical swine farm during 2014–2017. A total of 617 E. coli isolates were screened for the cfr gene using PCR amplification.
Zhenbao Ma, Jiao Liu, Lin Chen, Xiaoqin Liu, Wenguang Xiong, Jian-Hua Liu, Zhenling Zeng   +6 more
doaj   +1 more source

Whole genome sequencing,molecular typing and in vivovirulence of OXA-48-producingEscherichia coli isolates includingST131 H30-Rx, H22 and H41subclones [PDF]

, 2017
Carbapenem-resistant Enterobacteriaceae, including the increasingly reported OXA-48 Escherichia coli producers, are an emerging public health threat worldwide.
A Carattoli, A Carattoli, A Carrër, A Mora, A Potron, AHAM Hoek van, DR Zerbino, E Zankari, F Tanfous Ben, G Dahbi, G Gerhold, G Peirano, GC Cerqueira, J Blanco, J Fernández, J Fernández, JF Turton, JR Johnson, JR Johnson, K Power, KG Joensen, KG Joensen, L Chen, L Poirel, L Poirel, LW Riley, M Golebiewski, M-H Nicolas-Chanoine, MP Garcillán-Barcia, MV Larsen, N Stoesser, N-F Alikhan, NK Petty, O Clermont, O Clermont, P Nordmann, PL Ho, R Beyrouthy, R Beyrouthy, RR Spurbeck, S Ktari, SJ Weissman, SK Gupta, T Giani, T Wirth, TJ Johnson, VF Lanza, X Liu   +47 more
core   +7 more sources

Integrated Genomic and Phenotypic Characterization of an Mcr-10.1‐Harboring Multidrug Resistant Escherichia coli Strain From Migratory Birds in China

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Background: The global rise in antibiotic resistance among multidrug resistant (MDR) Gram‐negative (GN) bacteria has posed significant health challenges, leading to the resurgence of colistin as a key defense against these bacteria. However, the widespread use of colistin has resulted in the rapid emergence of colistin resistance on a global scale. Ten
Ronglei Huang, Xue Ji, Bing Liang, Bowen Jiang, Danhong Wang, Yi Tang, Chengyang Zhang, Ang Zhou, Nan Li, Chongtao Du, Yang Sun, Zongfu Wu   +11 more
wiley   +1 more source