Results 81 to 90 of about 1,672 (143)

Remarkable Diversity of Escherichia coli Carrying mcr-1 from Hospital Sewage with the Identification of Two New mcr-1 Variants

Frontiers in Microbiology, 2017
The plasmid-borne colistin-resistant gene mcr-1 has rapidly become a worldwide public health concern. This study aims to determine the host bacterial strains, plasmids, and genetic contexts of mcr-1 in hospital sewage.
Feifei Zhao, Feifei Zhao, Yu Feng, Yu Feng, Xiaoju Lü, Xiaoju Lü, Alan McNally, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +9 more
doaj   +1 more source

High rates of human fecal carriage of mcr-1-positive multi-drug resistant Enterobacteriaceae isolates emerge in China in association with successful plasmid families [PDF]

, 2017
Objectives mcr-1-mediated colistin resistance in Enterobacteriaceae is concerning, as colistin is used in treating multidrug-resistant Enterobacteriaceae infections. Rates of human mcr-1 gastrointestinal carriage have historically been low. We identified
Crook, DW, Doi, Y, Feng, LQ, Huang, X, Li, HY, Lin, J, Patil, S, Phan, HTT, Shen, C, Sheppard, AE, Stoesser, N, Tian, GB, Vihta, KD, Walker, Ann, Xia, Y, Zeng, KJ, Zhang, XF, Zhong, LL, Zing, Y   +18 more
core   +2 more sources

Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli [PDF]

, 2022
Introduction: The global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Bauerfeind, Rolf, Ewers, Christa, Göpel, Lisa, Kerner, Katharina, Prenger-Berninghoff, Ellen, Semmler, Torsten   +5 more
core   +2 more sources

Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost

Ecology and Evolution, Volume 14, Issue 8, August 2024.
In this review, we provide a comprehensive overview of the currently reported mechanisms underlying compensatory evolution on chromosomes and plasmids, elucidate key targets regulating plasmid fitness cost, and discuss future challenges in this field.
Ziyi Liu, Qiuyun Zhao, Chenggang Xu, Houhui Song   +3 more
wiley   +1 more source

Prevalence and molecular epidemiology of carbapenemase‐producing Enterobacterales isolated from dog and cat faeces submitted to veterinary laboratories in the USA

Zoonoses and Public Health, Volume 71, Issue 5, Page 538-548, August 2024.
Abstract Aims To estimate the prevalence of carbapenemase‐producing Enterobacterales (CPE) carriage among pets using faecal specimens submitted to veterinary diagnostic laboratories throughout the US. A secondary aim was to employ whole‐genome sequencing (WGS) to characterize isolates of CPE from companion animals and compare them to publicly available
Jaclyn Dietrich, Tessa E. LeCuyer, G. Kenitra Hendrix, Claire R. Burbick, Megan E. Jacob, Barbara A. Byrne, Karen Olsen, Maria Mitchell, Olgica Ceric, Rachel Lin, Jessica Joneson, Megan Lintner, Alexandra Fox, Diamond McClendon, Trevor Alexander, Kayla Joyce, Melissa Byrd, Jason Clinton, Keith Snipes, Laura Peak, Stephen D. Cole   +20 more
wiley   +1 more source

Genome sequences of two clinical Escherichia coli isolates harboring the novel colistin-resistance gene variants mcr-1.26 and mcr-1.27

Gut Pathogens, 2020
Background Colistin is still a widely used antibiotic in veterinary medicine although it is a last-line treatment option for hospitalized patients with infections caused by multidrug-resistant Gram-negative bacteria.
Bernd Neumann, Wiebke Rackwitz, Klaus-Peter Hunfeld, Stephan Fuchs, Guido Werner, Yvonne Pfeifer   +5 more
doaj   +1 more source

First report of the mobile colistin resistance gene, mcr-1.26, in multidrug-resistant Escherichia coli isolated from retail chicken meat

Journal of Global Antimicrobial Resistance, 2023
: Objectives: We isolated a highly colistin-resistant Escherichia coli, strain 58, from fresh chicken wings in Lebanon. Here, we performed in-depth phenotypic and genomic analyses to identify the resistome of the isolate, focusing on the determinants ...
Issmat I. Kassem, Marwan Osman, Jouman Hassan, Abdallah Alhaj Sulaiman, David Mann, Malak A. Esseili, Thierry Naas, Xiangyu Deng   +7 more
doaj   +1 more source

Whole Genome Sequencing and Characteristics of mcr-1–Harboring Plasmids of Porcine Escherichia coli Isolates Belonging to the High-Risk Clone O25b:H4-ST131 Clade B [PDF]

, 2020
Porcine Escherichia coli ST131 isolates are scarcely documented. Here, whole genome sequencing and core genome (CG) and plasmidome analysis of seven isolates collected from diarrheic piglets and four from pork meat were performed.
Blanco Álvarez, Jorge, Díaz Jiménez, Dafne, Flament Simon, Saskia Camille, García Meniño, Isidro, García Menéndez, Vanesa, Herrera Estévez, Alexandra, Mora Gutiérrez, Azucena, Toro, María de   +7 more
core   +1 more source

Microbial evolution through horizontal gene transfer by mobile genetic elements

Microbial Biotechnology, Volume 17, Issue 1, January 2024.
This mini‐review explores the behaviour of conjugative plasmids in various environments, discusses recent methodologies for tracking mobile genetic elements (MGE) dynamics, and underscores the importance of understanding horizontal gene transfer (HGT) mechanisms to develop effective strategies against antimicrobial resistance genes (ARGs) dissemination.
Maho Tokuda, Masaki Shintani
wiley   +1 more source

A Large Spatial Survey of Colistin-Resistant Gene mcr-1-Carrying E. coli in Rivers across Taiwan

Microorganisms, 2021
Background: Colistin is one of the last-line antimicrobial agents against life-threatening infections. The distribution of the colistin resistance gene mcr-1 has been reported worldwide.
Ching-Hao Teng, Pin-Chieh Wu, Sen-Lin Tang, Yi-Chen Chen, Ming-Fang Cheng, Ping-Chih Huang, Wen-Chien Ko, Jiun-Ling Wang   +7 more
doaj   +1 more source