Results 11 to 20 of about 10,572 (203)

Simulation of the Metabolism of New Psychoactive Substances Using Electrochemistry-Mass Spectrometry: Introducing an Innovative Software Tool for Rapid Data Evaluation. [PDF]

Drug Test Anal
A novel software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances was developed and applied to mimic the metabolism of the synthetic cannabinoid receptor agonist MDMB‐4en‐PINACA. ABSTRACT An innovative software tool for the rapid and efficient simulation of the metabolism of new psychoactive substances (NPS ...
Wesner M, Heuckeroth S, Pütz M, Karst U.   +3 more
europepmc   +2 more sources

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors. [PDF]

Angew Chem Int Ed Engl
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Xu Z, Mukherjee P, Gossert S, Thomas S, Vasilev VH, Welin ER, Tan Y, McKenna SM, Emmanuel MA, Hyster TK.   +9 more
europepmc   +3 more sources

Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives

Molecules, 2018
Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. Diversely substituted indazole derivatives bear a variety of functional groups and display versatile biological activities; hence, they have gained ...
Shu-Guang Zhang, Chao-Gen Liang, Wei-Hua Zhang   +2 more
doaj   +1 more source

Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. [PDF]

, 2012
The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good ...
Andreas Unsinn, Batt, Bunnell, Bunnell, Chevallier, Clutterbuck, Collot, Crestey, Despotopoulou, Dong, Dunst, Farina, Fraile, Haag, Haag, Kienle, Knochel, Luo, Malamas, Mulvey, Negishi, Negishi, Negishi, Negishi, Negishi, Ohnmacht, Pabba, Paul Knochel, Perez, Peruncheralathan, Piazza, Pyne, Schmidt, Stadlbauer, Sun, Villieras, Welch, Whisler, Wunderlich, Wunderlich, Yang   +40 more
core   +1 more source

Pd(PPh₃)₄ Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Applied Sciences, 2020
A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches.
Jagan Mohana Rao Saketi, S. N. Murthy Boddapati, Raghuram M., Syed Farooq Adil, Mohammed Rafi Shaik, Osamah Alduhaish, Mohammed Rafiq H. Siddiqui, Hari Babu Bollikolla   +7 more
doaj   +1 more source

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists [PDF]

, 2014
A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme.
Copley, R.C.B., Miah, A.H., O'Flynn, D., Percy, J.M., Procopiou, P.A.   +4 more
core   +1 more source

Rhodium(I) indazole and indazolate complexes

Journal of Organometallic Chemistry, 1982
The preparation of cationic indazole (HIdz) rhodium(I) complexes of the types [(diolefin)Rh(HIdz)2]ClO4 and [(CO)2Rh(HIdz)2]ClO4 is described. Neutral binuclear rhodium(I) complexes of the type [Y2Rh(μ-Idz)]2 (Y2 = COD, TFB, NBD, (CO)2 or (CO)(PPh3)) are obtained by treating the corresponding complexes [Y2RhCl]2 with indazole and organic or inorganic ...
Usón, Rafael, Oro, Luis A., Ciriano, Miguel A., Bello, M. C.   +3 more
openaire   +2 more sources

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P., Dvorácskó, Szabolcs, MINOSI, PAOLA, MOLLICA, Adriano, PIERETTI, Stefano, Stefanucci, Azzurra, Tömböly, Csaba, Zengin, Gokhan   +7 more
core   +2 more sources

Unusual DNA binding modes for metal anticancer complexes [PDF]

, 2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core   +1 more source

Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2H-indazole Hybrids

Pharmaceuticals, 2021
Cancer is the second leading cause of death, after cardiovascular diseases. Different strategies have been developed to treat cancer; however, chemotherapy with cytotoxic agents is still the most widely used treatment approach.
Jaime Pérez-Villanueva, Félix Matadamas-Martínez, Lilián Yépez-Mulia, Vadim Pérez-Koldenkova, Martha Leyte-Lugo, Karen Rodríguez-Villar, Francisco Cortés-Benítez, Ana Perla Macías-Jiménez, Ignacio González-Sánchez, Ariana Romero-Velásquez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche   +11 more
doaj   +1 more source