Results 31 to 40 of about 10,572 (203)

Synthesis of indazolo[5,4-b][1,6]naphthyridine and indazolo[6,7-b][1,6]naphthyridine derivatives

Heterocyclic Communications, 2019
A simple method for the synthesis of the title compounds by an efficient in-situ reduction and cyclization reactions of aromatic aldehydes, tert-butyl 2,4-dioxopiperidine-1-carboxylate and 5-nitro-1H-indazole or 6-nitro-1H-indazole was developed.
Chen Dong-Mei, Liu Jia-Yan, Wei Ming, Wang Bing-Wei, Chu Ruo-Han, Chen Dong-Sheng   +5 more
doaj   +1 more source

Structure-based optimization of potent, selective, and orally bioavailable CDK8 inhibitors discovered by high-throughput screening [PDF]

, 2016
The mediator complex-associated cyclin dependent kinase CDK8 regulates beta-catenin-dependent transcription following activation of WNT signaling. Multiple lines of evidence suggest CDK8 may act as an oncogene in the development of colorectal cancer ...
Aurélie Mallinger, Christina Esdar, Daniel Schwarz, Dirk Wienke, Djordje Musil, Felix Rohdich, Florence I. Raynaud, Julian Blagg, Kai Schiemann, Klaus Urbahns, Maria-Jesus Ortiz-Ruiz, Michael Busch, Oliver Pöschke, Paul A. Clarke, Paul Czodrowski, Richard Schneider, Rickert P., Suzanne A. Eccles, Trevor Dale   +18 more
core   +4 more sources

Estrogen Receptor Transrepresses Brain Inflammation [PDF]

, 2011
Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al.
Gosselin, David, Rivest, Serge
core   +1 more source

Tris[2-(2H-indazol-2-yl)ethyl]amine

Acta Crystallographica Section E, 2012
The title tertiary amine, C27H27N7, a potential tripodal ligand for coordination chemistry, crystallizes with the central N atom located on a threefold axis of a trigonal cell. The gauche conformation of the N(amime)—CH2—CH2—
Saúl Ovalle, Perla Elizondo Martínez, Nancy Pérez Rodríguez, Sylvain Bernès, Marcos Flores-Alamo   +4 more
doaj   +1 more source

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model. [PDF]

, 2020
Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden unexplained death in epilepsy (SUDEP).
Anvar, Mana, Baraban, Scott C, Griffin, Aliesha, Hamling, Kyla   +3 more
core   +1 more source

N-(INDAZOLYL)BENZAMIDO DERIVATIVES AS CDK1 INHIBITORS: DESIGN, SYNTHESIS, BIOLOGICAL ACTIVITY, AND MOLECULAR DOCKING STUDIES [PDF]

, 2009
A series of N-1H-indazole-1-carboxamides have been synthesized and their effects on both CDK1/cyclin B and K-562 (human chronic myelogenus leukemia) cell line were evaluated.
Arris, Candurri, Candurri, Carmicael, Daidone, Davies, Davies, de Azevedo, Fabbro, Furet, Gray, Jeffrey, Knockaert, Korbonits, Manfredini, McGrath, Raffa, Raffa, Schulze-Gahmen, Smith, Toogood, Valgeirsson   +21 more
core   +1 more source

Synthesis of 1,3-substituted 1H-indazole derivatives and evaluation of anti-inflammatory activity in Sprague Dawley rats

Intelligent Pharmacy
Indazole is a very significant group of heterocyclics. Aim of the research was thus planned to synthesize novel derivatives of indazole and evaluate their anti-inflammatory activity.
Vishal Kumar, Anup Kumar Sirbaiya, Md Nematullah, Md Faheem Haider, Md Azizur Rahman   +4 more
doaj   +1 more source

Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization [PDF]

, 2009
Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,
Antunes, Inês F., Curto, M. João M., Neves, M., Teixeira, António P. S., Teixeira, Fátima C.   +4 more
core   +2 more sources

Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives

Molecules, 2016
A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor.
Efrain Polo, Jorge Trilleras, Juan Ramos, Antonio Galdámez, Jairo Quiroga, Margarita Gutierrez   +5 more
doaj   +1 more source

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

Beilstein Journal of Organic Chemistry, 2016
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis.
Manjunatha Narayanarao, Lokesh Koodlur, Vijayakumar G. Revanasiddappa, Subramanya Gopal, Susmita Kamila   +4 more
doaj   +1 more source