Results 41 to 50 of about 10,572 (203)

3-Isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione

Molbank, 2022
Here we describe the functionalization of lupulone natural compound in obtaining 3-isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione.
José Edmilson Ribeiro do Nascimento, Daniela Hartwig, Raquel Guimarães Jacob, Márcio Santos Silva   +3 more
doaj   +1 more source

An index of fatal toxicity for new psychoactive substances [PDF]

, 2018
The final, definitive version of this paper has been published in Journal of Psychopharmacology, February 2018, published by SAGE Publishing, All rights reserved.An index of fatal toxicity for new psychoactive substances has been developed based solely ...
Corkery, John, King, L.A.
core   +2 more sources

New 1H-Benzo[f]indazole-4,9-diones Conjugated with C-Protected Amino Acids and Other Derivatives: Synthesis and in Vitro Antiproliferative Evaluation

Molecules, 2015
1H-Benzo[f]indazole-4,9-dione derivatives conjugated with C-protected amino acids (glycine, l-alanine, l-phenylalanine and l-glutamic acid) 6a–l were prepared by chemically modifying the prenyl substituent of 3-methyl-7-(4-methylpent-3-enyl)-1H-benzo[f ...
Aurora Molinari, Alfonso Oliva, Marlene Arismendi-Macuer, Leda Guzmán, Mauricio Fuentealba, Marcela Knox, Raúl Vinet, Arturo San Feliciano   +7 more
doaj   +1 more source

“On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole

Molecules, 2020
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3 ...
Khadija Gambouz, Abdelmoula El Abbouchi, Sarah Nassiri, Franck Suzenet, Mostapha Bousmina, Mohamed Akssira, Gérald Guillaumet, Saïd El Kazzouli   +7 more
doaj   +1 more source

Heroin Adulterated with the Novel Synthetic Cannabinoid, 5F-MDMB-PINACA: A Case Series [PDF]

, 2020
Introduction: Heroin can be adulterated with various substances that may or may not have pharmacological effects. Here we report a case series of 8 patients who presented to the emergency department after overdose with intravenous heroin preparation ...
Arnold, Ryan, Dela Cruz, Maricel, Ershad, Muhammed, Hamilton, Richard, Khalid, Muhammad M., Mostafa, Ahmed   +5 more
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Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors

Molecules, 2016
Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5 ...
Zhen Zhang, Dongmei Zhao, Yang Dai, Maosheng Cheng, Meiyu Geng, Jingkang Shen, Yuchi Ma, Jing Ai, Bing Xiong   +8 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
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Хлорфенолы в органическом синтезе [PDF]

, 2016
Received: 17.08.2016; accepted: 11.10.2016; published: 01.12.2016.Поступило: 17.08.2016; приянято: 11.10.2016; опубликовано: 01.12.2016.This article reviews the alternatives for modifications of p-chlorophenols, p-chloroanisoles with the formation of C-C,
Ivanova, E. A., Mitin, V. V., Morzherin, Yu. Yu., Prokhorova, P. E., Иванова, Е. А., Митин, В. В., Моржерин, Ю. Ю., Прохорова, П. Е.   +7 more
core   +1 more source

Recent Advances in Indazole-Derived Heterocycles: Synthetic Strategies, Functionalization, and Therapeutic Potential

Journal of Chemistry
Indazole-derived heterocycles have garnered significant attention in recent years due to their versatile chemical structures and wide-ranging biological activities. This review explores the recent progress in the synthesis of indazole-based heterocycles,
Uday V. Bhat, Glanish Jude Martis, Dinesh Chikkanna, Santosh L. Gaonkar   +3 more
doaj   +1 more source

New indazole-indolizine-triazine hybrid molecules with farnesyltransferase inhibitory activity

Results in Chemistry
A new series of indazole-indolizine-triazine hybrid molecules was obtained by [3 + 2] cycloaddition reaction between newly synthesized nitrogen ylides with indazole skeleton and previously reported dipolarophile 2‐ethynyl‐4,6‐dimethoxy‐1,3,5‐triazine and
Liliana Ciurlă-Lucescu, Elena Bîcu, Dalila Belei, Alina Ghinet   +3 more
doaj   +1 more source