Results 61 to 70 of about 10,572 (203)

Identification and development of novel indazole derivatives as potent bacterial peptidoglycan synthesis inhibitors

International Journal of Mycobacteriology, 2018
Background: Tuberculosis is well-known airborne disease caused by Mycobacterium tuberculosis. Available treatment regimen was unsuccessful in eradicating the deaths caused by the disease worldwide.
Prasanthi Malapati, Vagolu Siva Krishna, Sriram Dharmarajan   +2 more
doaj   +1 more source

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

1-Chloro-3-(6-nitro-1H-indazol-1-yl)propan-2-ol

IUCrData, 2017
In the title compound, C10H10ClN3O3, the side chain is oriented nearly perpendicular to the mean plane of the indazole ring system. In the crystal, complementary sets of O—H...N and C—H...O hydrogen bonds form chains of molecules stacked along the a-axis
Mohamed Mokhtar Mohamed Abdelahi, Youness El Bakri, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents

Molecules, 2022
The current work presents an objective overview of the impact of one important heterocyclic structure, the pyrazole ring, in the development of anti-proliferative drugs. A set of 1551 pyrazole derivatives were extracted from the National Cancer Institute
George Mihai Nitulescu
doaj   +1 more source

Substitutive Approach Toward Heteroaromatic Amino Alcohols Accessed Through Dioxolanyl Radical Linchpin

Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
A dioxolanyl linchpin has been used to synthesize aryl ethanolamines from readily available aryl bromide and amine starting materials using a metallaphotoredox/substitution telescoped sequence. This combinatorial approach allows for a wide synthetic scope of both heteroarenes and cyclic amines. Aryl ethanolamines are an important functional group found
Justin J. Chang, Munnu Kumar, Ryan C. Kashatus, Dylan J. Tomaselli, Daniel K. Kim   +4 more
wiley   +1 more source

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies [PDF]

, 2013
Indazolium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1019) and its Na+ analogue (KP1339) are two of the most prominent non-platinum antitumor metal complexes currently undergoing clinical trials.
A Küng, Anna K. Bytzek, AR Timerbaev, AV Rudnev, B Valeur, Bernhard K. Keppler, C Dittrich, C Scolaro, CF Chignell, CG Hartinger, CG Hartinger, CG Hartinger, Christian G. Hartinger, D Buttar, DC Carter, DE Epps, EL MacKenzie, Eva A. Enyedy, F Lentz, G Fanali, G Sava, G Sava, G Sudlow, I Bertini, JM Rademaker-Lakhai, JR Lakowicz, K Oettl, K Polec-Pawlak, L Trynda-Lemiesz, L Zékány, M Galanski, M Groessl, M Sulyok, MA Jakupec, MI Webb, MI Webb, MJ Clarke, MJ Clarke, N Cetinbas, N Muller, ND Chasteen, Orsolya Dömötör, RA Gatenby, RA Weisiger, S Kapitza, S Kapitza, SS Aleksenko, T Peters, T Peters Jr, T Pieper, Tamás Kiss, TC Pinkerton, V Brabec, WH Ang, XM He, Y Jung, ÉA Enyedy, ÉA Enyedy   +57 more
core   +1 more source

Synthesis of Niraparib via Chemoenzymatic Dearomatization of Substituted Pyridines

Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
The synthesis of the PARP inhibitor Niraparib has been achieved via a chemoenzymatic dearomatization strategy. Chemical reduction combined with a one‐pot enzymatic cascade comprising an amine oxidase (AmOx) and an ene imine reductase (EneIRED) allowed for asymmetric reduction with high enantioselectivity.
Tabea Gerlach, Lucian Pirvu, Sam Butterworth, Nicholas J. Turner   +3 more
wiley   +1 more source

Predicting melting points of organic molecules : applications to aqueous solubility prediction using the General Solubility Equation [PDF]

, 2015
In this work we make predictions of several important molecular properties of academic and industrial importance to seek answers to two questions: 1) Can we apply efficient machine learning techniques, using inexpensive descriptors, to predict melting ...
McDonagh, James, Mitchell, John B. O., van Mourik, Tanja   +2 more
core   +1 more source

Electro‐Mediated Redox Functionalization of Conjugated 1,3‐Dienes

Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
This review aims at providing a comprehensive view of the emerging field of electro‐mediated functionalization of conjugated 1,3‐dienes, highlighting key developments, mechanistic insights, and remaining challenges. It highlights the efficient use of electron as the sole reagent to access highly substituted allylic compounds from simple and readily ...
Ophélie Montiège, Jean‐François Brière, Cédric Schneider, Hélène Beucher   +3 more
wiley   +1 more source

Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives

Intelligent Pharmacy
Aim of the study was designed to synthesize and evaluate antibacterial activity of novel heterocyclic compounds, 3-methyl-1H-indazole derivatives. The heterocyclic compounds, 3-methyl-1H-indazole derivatives (1a-1d and 2a-2d) were synthesized; all of ...
Farrukh Shaikh, Muhammad Arif, Mohammad Khushtar, Md Nematullah, Md Azizur Rahman   +4 more
doaj   +1 more source