Results 71 to 80 of about 10,572 (203)

Crystal structure of 2-[(3aS,6R)-3,3,6-trimethyl-3,3a,4,5,6,7-hexahydro-2H-indazol-2-yl]thiazol-4(5H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, C13H19N3OS, is a new thiazolidin-4-one derivative prepared and isolated as the pure (3aS,6R)-diastereisomer from (R)-thiosemicarbazone pulegone. It crystallized with two independent molecules (A and B) in the asymmetric unit.
Abdellah N'ait Ousidi, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Jean-Claude Daran, Auhmani Abdelwahed   +5 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening.
Jian Liu, Yu Wen, Lina Gao, Liang Gao, Fengjun He, Jingxian Zhou, Junwei Wang, Rupeng Dai, Xiaojing Chen, Di Kang, Lihong Hu   +10 more
doaj   +1 more source

Copper Coordination Materials for Selective CO2 Electroreduction Toward Multi‐Carbon Products

Carbon Neutralization, Volume 5, Issue 2, March 2026.
This review summarizes recent advances in Cu‐based coordination catalysts for electrochemical CO2 reduction reaction (CO2RR) toward multi‐carbon products. It focuses on key kinetics such as C–C coupling, and outlines design strategies and catalytic mechanisms of various Cu‐based coordination materials.
Jinze Yang, Xiaoqing Yao, Yan Wang, Siyu Lu, Jiajia Huang, Tanglue Feng   +5 more
wiley   +1 more source

Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C22H18N2O4, the three fused rings of the pyrazolophthalazine moiety are coplanar (r.m.s. deviation = 0.027 Å). The cyclohexene ring fused to the pyrazolidine ring, so forming the indazolophthalazine unit, has a half-chair ...
Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Zouhair Bouaziz   +4 more
doaj   +1 more source

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 ...
Daseul Im, Joonhong Jun, Jihyun Baek, Haejin Kim, Dahyun Kang, Hyunah Bae, Hyunwook Cho, Jung-Mi Hah   +7 more
doaj   +1 more source

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability [PDF]

, 2016
The discontinuation of PAR-1 antagonist RWJ-58259 beyond use as a biological probe is most likely due to it's short half-life in vivo. However, retention of significant in vivo activity beyond the point where most of the RWJ-58259 had been consumed ...
Caddick, S, Chambers, RC, Chudasama, V, Inglis, GG, Knight, E, Robinson, E, Smoktunowicz, N   +6 more
core   +1 more source

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, Volume 18, Issue 3, Page 334-340, March 2026.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source

New azo disperse dyes containing cyclohexanone ring for dyeing polyester and nylon fabrics

Macedonian Journal of Chemistry and Chemical Engineering, 2010
Condensation of 2,4-diacarboethoxy-5-hydroxy-3-(4-methoxyphenyl)-5-methyl cyclohexanone (1) with equimolar amounts of hydrazine hydrate and phenyl hydrazine afforded the corresponding 2H-indazole-5-carboxylates 2a and 2b, respectively.
Hatem E. Gaffer, Mohamed A. E. Khalifa, Shaima F. El-Bially, Mohamed A. Metwally   +3 more
doaj   +1 more source

The synthesis and characterization of the 'research chemical' N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer. [PDF]

This study presents the identification of N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide that was termed 3,5-AB-CHMFUPPYCA.
Behonick, Brandt, Castaneto, Chung, Drug Enforcement Administration, Department of Justice, Drug Enforcement Administration, Department of Justice, Erratico, Gatch, Girreser, Hasegawa, Hasegawa, Huppertz, Kikura-Hanajiri, King, Schwartz, Takayama, Thomsen, Uchiyama, Uchiyama, Uchiyama, Uchiyama, Uchiyama, Westphal, Wohlfarth, Wurita   +24 more
core   +1 more source

Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease. [PDF]

, 2016
A four step process of high quality modelling of existing data, deconstruction, identification of replacement cores and an innovative synthetic re-growth strategy led to the rapid discovery of a novel oral series of PI3K δ inhibitors with promising ...
Anthony W. J. Cooper, Augustin Amour, Chris Tame, Christopher N. Luscombe, Craig Jamieson, David Perez, Giovanni Vitulli, Graham Inglis, Josie Morrell, Natalie Wellaway, Nick Barton, Paul Rowland, Simon Peace, Sorif Uddin   +13 more
core   +1 more source