Results 1 to 10 of about 5,005 (186)

Nitroreductase-triggered indazole formation [PDF]

Nature Communications
Biocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen, Lisa Medema, Elizaveta Chernyshova, Alejandro Prats Luján, Gerrit J. Poelarends, Sandy Schmidt   +5 more
doaj   +5 more sources

Indazole: Photoleitfähigkeit und Oxidationspotentiale [PDF]

CHIMIA, 1988
In sensitized electrophotographic layers, excellent charge transport properties are exhibited by 2-(p-aminophenyl)indazoles (1). Corresponding 2-aminoindazoles (2) are ineffective.
Bernhard Albert, Peter Neumann, Gerhard Hoffmann   +2 more
doaj   +4 more sources

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles [PDF]

Molecules, 2016
A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl ...
Mei-Huey Lin, Kung-Yu Liang, Chang-Hsien Tsai, Yu-Chun Chen, Hung-Chang Hsiao, Yi-Syuan Li, Chung-Hao Chen, Hau-Chun Wu   +7 more
doaj   +3 more sources

Synthesis of CF₃-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF₃-Imidoyl Sulfoxonium Ylides [PDF]

Molecules
An efficient Rh(III)-catalyzed C-H activation of azobenzenes and subsequent [4+1] cascade annulation with CF3-imidoyl sulfoxonium ylides was developed, yielding diverse CF3-indazoles.
Yilong Shang, Chen Li, Guiqiu Wang, Guiwei Yao, Hongliang Wu, Xun Chen, Ruirui Zhai   +6 more
doaj   +2 more sources

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds [PDF]

Molecules
Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science.
Catarina M. Correia, Artur M. S. Silva, Vera L. M. Silva   +2 more
doaj   +2 more sources

Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles [PDF]

Bulletin of Chemical Reaction Engineering & Catalysis, 2018
A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst.
Bashir Ahmad Dar, Syed Wasim Safvi, Masood Ahmad Rizvi   +2 more
doaj   +4 more sources

Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles. [PDF]

J Org Chem
A copper-catalyzed intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C–N bond formation and a subsequent 1,2-hydride shift, affording products in high yields.
Mañas C, Herrero-Bourdieu J, Merino E.
europepmc   +3 more sources

Synthesis of N-phenyl- and N-thiazolyl-1H-indazoles by copper-catalyzed intramolecular N-arylation of ortho-chlorinated arylhydrazones

Beilstein Journal of Organic Chemistry, 2022
The broad application of 1H-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular N-arylation of in situ-generated or isolated o ...
Yara Cristina Marchioro Barbosa, Guilherme Caneppele Paveglio, Claudio Martin Pereira de Pereira, Sidnei Moura, Cristiane Storck Schwalm, Gleison Antonio Casagrande, Lucas Pizzuti   +6 more
doaj   +1 more source

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

Beilstein Journal of Organic Chemistry, 2021
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient ...
Ryan M. Alam, John J. Keating
doaj   +1 more source

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions [PDF]

Royal Society Open Science, 2018
The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo ...
Scott H. Henderson, Ryan A. West, Simon E. Ward, Mark A. Honey   +3 more
doaj   +1 more source