Results 41 to 50 of about 5,024 (202)

Pd(PPh₃)₄ Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

Applied Sciences, 2020
A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches.
Jagan Mohana Rao Saketi, S. N. Murthy Boddapati, Raghuram M., Syed Farooq Adil, Mohammed Rafi Shaik, Osamah Alduhaish, Mohammed Rafiq H. Siddiqui, Hari Babu Bollikolla   +7 more
doaj   +1 more source

The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole

Crystals, 2012
Two novel indazole derivatives protected with p-methoxybenzyl group were synthesized and characterized. The crystal and molecular structure of 2-(4-methoxybenzyl)-4-nitro-2H-indazole as one out of the two regioisomers is reported.
Constantin Mamat, Martin Köckerling, Kristin Ebert   +2 more
doaj   +1 more source

Study of the Differential Activity of Thrombin Inhibitors Using Docking, QSAR, Molecular Dynamics, and MM-GBSA [PDF]

, 2015
Indexación: Web of Science; Scopus.Non-peptidic thrombin inhibitors (TIs; 177 compounds) with diverse groups at motifs P1 (such as oxyguanidine, amidinohydrazone, amidine, amidinopiperidine), P2 (such as cyano-fluorophenylacetamide, 2-(2-chloro-6 ...
Caballero, J., Mena-Ulecia, K., Tiznado, W.   +2 more
core   +3 more sources

Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides [PDF]

, 2013
An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand ...
Buchwald, Stephen Leffler, Hoshiya, Naoyuki, Su, Mingjuan   +2 more
core   +1 more source

The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

Molecules, 2012
The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave ...
Chiara Oliviero, Tecla Gasperi, Maria Antonietta Loreto, Antonella Migliorini   +3 more
doaj   +1 more source

Rh(III)-catalyzed C–H acylmethylation of 2H-indazoles with sulfoxonium ylides

Journal of Saudi Chemical Society, 2020
An efficient Cp*Rh(III)-catalyzed direct acylmethylation of 2H-indazoles with sulfoxonium ylides has been realized under air atmosphere via chelation-assisted strategy.
Ya-Gai Wang, Jing Li, Xiao-Die Wang, Linlin Shi, Xinju Zhu, Xin-Qi Hao, Mao-Ping Song   +6 more
doaj   +1 more source

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity

Molecules, 2019
New substituted benzo[g]indazoles functionalized with a 6-nitro and 6-amino groups have been synthesized by the reaction of benzylidene tetralones with hydrazine in acetic acid.
Viviana Cuartas, María del Pilar Crespo, Eva-María Priego, Leentje Persoons, Dirk Daelemans, María-José Camarasa, Braulio Insuasty, María-Jesús Pérez-Pérez   +7 more
doaj   +1 more source

Diamine ligands in copper-catalyzed reactions [PDF]

, 2010
The utility of copper-mediated cross-coupling reactions has been significantly increased by the development of mild reaction conditions and the ability to employ catalytic amounts of copper.
Buchwald, Stephen Leffler, Surry, David S.   +1 more
core   +2 more sources

A Metal-Free Regioselective Multicomponent Approach for the Synthesis of Free Radical Scavenging Pyrimido-Fused Indazoles and Their Fluorescence Studies

Molecules, 2016
This study deals with a new and efficient metal-free regioselective synthesis of pyrimido-fused indazoles with nitrogen ring junction motifs. We have developed a metal-free domino type reaction between 3-aminoindazole, aryl aldehydes and aceotophenones ...
Jeyakannu Palaniraja, Selvaraj Mohana Roopan, G Mokesh Rayalu, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu   +4 more
doaj   +1 more source

Chemical composition of Nigella sativa Linn : Part 2 Recent advances [PDF]

, 2016
The black cumin or Nigella sativa L. seeds have many acclaimed medicinal properties such as bronchodilatory, hypotensive, antibacterial, antifungal, analgesic, anti-inflammatory and immunopotentiating.
Afzal, M, Khan, Akram
core   +1 more source