Synthesis of Niraparib via Chemoenzymatic Dearomatization of Substituted Pyridines
Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.The synthesis of the PARP inhibitor Niraparib has been achieved via a chemoenzymatic dearomatization strategy. Chemical reduction combined with a one‐pot enzymatic cascade comprising an amine oxidase (AmOx) and an ene imine reductase (EneIRED) allowed for asymmetric reduction with high enantioselectivity.
Tabea Gerlach +3 more
wiley +1 more source
Synthesis and Broad-Spectrum Antiviral Activity of Some Novel Benzo-Heterocyclic Amine Compounds [PDF]
, 2014 A series of novel unsaturated five-membered benzo-heterocyclic amine derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities.
Alter +11 more
core +1 more source
Electro‐Mediated Redox Functionalization of Conjugated 1,3‐Dienes
Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.This review aims at providing a comprehensive view of the emerging field of electro‐mediated functionalization of conjugated 1,3‐dienes, highlighting key developments, mechanistic insights, and remaining challenges. It highlights the efficient use of electron as the sole reagent to access highly substituted allylic compounds from simple and readily ...
Ophélie Montiège +3 more
wiley +1 more source
Sinteza, protuupalno, analgetsko i antikonvulzivno djelovanje 1,8-dihidro-1-aril-8-alkil pirazolo(3,4-b)indola [PDF]
, 2010 A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities.
ADEL H. MANDOUR +3 more
core +3 more sources
Copper Coordination Materials for Selective CO2 Electroreduction Toward Multi‐Carbon Products
Carbon Neutralization, Volume 5, Issue 2, March 2026.This review summarizes recent advances in Cu‐based coordination catalysts for electrochemical CO2 reduction reaction (CO2RR) toward multi‐carbon products. It focuses on key kinetics such as C–C coupling, and outlines design strategies and catalytic mechanisms of various Cu‐based coordination materials.
Jinze Yang +5 more
wiley +1 more source
Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization [PDF]
, 2009 Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,
Antunes, Inês F. +4 more
core +2 more sources
Drug Testing and Analysis, Volume 18, Issue 3, Page 334-340, March 2026.MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi +6 more
wiley +1 more source
Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
CHIMIA, 2003 Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers.
Peter Schäfer +4 more
doaj +1 more source
Синтез нових біс-a, b-ненасичених похідних 4-метилциклогексанону - напівпродуктів для одержання біологічно активних гетероциклів [PDF]
, 2004 Одержано низку нових біс-a, b-ненасичених кетонів конденсацією 4-метилциклогексанону з ароматичними та гетероциклічними альдегідами. Досліджено їх фізичні та спектральні властивості; показана можливість їх застосування для синтезу нових п`ятичленних ...
Листван, В. В.
core
Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide [PDF]
, 2010 Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This perspective attempts to aid the reader in the selection of the best choice of reaction conditions and ligand ...
Buchwald, Stephen Leffler +1 more
core +1 more source