Results 171 to 180 of about 4,853 (196)

An indirubin derivative, E804, exhibits potent angiosuppressive activity

Biochemical Pharmacology, 2012
Angiogenesis, the development of neovessels from pre-existing vessels, is obligatory for solid tumors survival, growth, invasion, and metastasis. Many anti-angiogenic agents are small molecules originated from natural sources. Recently, angiosuppressive effects of indirubin and its derivatives, the active components in indigo-producing herbs, have been
Yuk-Kit, Chan, Hoi-Hin, Kwok, Lai-Sheung, Chan, Kelvin Sze-Yin, Leung, Jue, Shi, Nai-Ki, Mak, Ricky Ngok-Shun, Wong, Patrick Ying-Kit, Yue   +7 more
openaire   +2 more sources

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

Bioorganic & Medicinal Chemistry, 2010
Indirubins have been reported to act as potent inhibitors of protein kinases relevant to tumorigenesis and of tumor cell growth, but their development to antitumor drugs suffer from their poor water solubility. We synthesized a novel class of indirubin derivatives, indirubin-5-carboxamides, carrying amide substituents with basic centers. Quaternization
Xinlai, Cheng, Paul, Rasqué, Sandra, Vatter, Karl-Heinz, Merz, Gerhard, Eisenbrand   +4 more
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Novel Synthesis of 4- or 6-Substituted Indirubin Derivatives

Synthetic Communications, 2010
A simple and convenient route for synthesis of a series of 4- or 6-substituted indirubin derivatives by oxidation and subsequent condensation of indoxyl and isatin is described. Acidic reaction conditions are crucial to the condensation of 4-substituted derivatives, whereas for the condensation of 6-substituted derivatives, both acidic and basic ...
Aiying Zhang, Mingfeng Yu, Tian Lan, Zenglu Liu, Zhenmin Mao   +4 more
openaire   +2 more sources

First synthesis of indirubin N-glycosides (red sugars)

Tetrahedron Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stefanie Libnow, Martin Hein, Dirk Michalik, Peter Langer   +3 more
openaire   +1 more source

5′-OH-5-nitro-Indirubin oxime (AGM130), an Indirubin derivative, induces apoptosis of Imatinib-resistant chronic myeloid leukemia cells

Leukemia Research, 2013
Imatinib is a highly effective drug for the treatment of chronic myeloid leukemia (CML) that targets the BCR-ABL kinase. However, a number of patients have CML that is resistant to Imatinib treatment. In this report, we developed AGM130 as a potential therapeutic drug for Imatinib-resistant CML treatment.
Woo-Seok, Kim, Min-Jung, Lee, Do-Hyung, Kim, Jung-Eun, Lee, Jae-Il, Kim, Yong-Chul, Kim, Mi-Ryoung, Song, Sung-Gyoo, Park   +7 more
openaire   +2 more sources

HYDROXYLATED INDIRUBIN DERIVATIVES

2004
The present invention relates to hydroxylated indirubin derivatives having the formula (I) wherein the group R represents a straight-chain or branched-chain alkyl group or a straight chain or branched-chain alkoxy group each having 1 to 18 carbon atoms, the group R' represents H, a straight-chain or branched-chain alkyl group having 1 to 4 carbon atoms
EISENBRAND GERHARD, HIPPE FRANKIE
openaire   +1 more source

[Synthesis of some halogenated indirubin derivatives].

Yao xue xue bao = Acta pharmaceutica Sinica, 1990
Indirubin has been used clinically to treat chronic granulocytic leukemia, but poor solubility limited its absorption in the body. In order to reduce its side effect and raise its therapeutic effect on chronic granulocytic leukemia, six halogen-substituted derivatives were synthesized.
Y C, Gu, G L, Li, Y P, Yang, J P, Fu, C Z, Li   +4 more
openaire   +1 more source

Molecular targets of indirubins

Int. Journal of Clinical Pharmacology and Therapeutics, 2005
S, Jakobs, K H, Merz, S, Vatter, G, Eisenbrand   +3 more
openaire   +2 more sources

Indirubin and Indirubin Derivatives

2008
Gerhard Eisenbrand, Karl-Heinz Merz
openaire   +1 more source

indirubin, n.

2023
openaire   +1 more source