Results 21 to 30 of about 17,012 (208)

Indole-3-Lactic Acid Inhibits Doxorubicin-Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway. [PDF]

J Cell Mol Med
ABSTRACTThe clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and myocardial ferroptosis. This study aimed to investigate the role of the gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), in mitigating DOX‐
Lian J, Lin H, Lin H, Zhong Z, Song Y, Shao X, Zhou J, Xu L, Sun Z, Yang Y, Chi J, Wang P, Meng L.   +12 more
europepmc   +5 more sources

Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models. [PDF]

Int J Mol Sci, 2022
Indole-3-lactic acid (I3LA) is a well-known metabolite involved in tryptophan metabolism. Indole derivatives are involved in the differentiation of immune cells and the synthesis of cytokines via the aryl hydrocarbon receptors for modulating immunity, and the indole derivatives may be involved in allergic responses.
Kim K, Kim H, Sung GY.
europepmc   +5 more sources

Synbiotics of Lactobacillus suilingensis and inulin alleviates cognitive impairment via regulating gut microbiota indole-3-lactic acid metabolism in female AD mice. [PDF]

Alzheimers Dement
AbstractINTRODUCTIONRecent studies have found that gut microbial tryptophan metabolism is altered in Alzheimer's disease (AD) patients. However, the functional consequences of these changes and their therapeutic potential remain unclear.METHODSThe metagenomic data of 49 preclinical AD patients and 115 healthy controls were analyzed.
Yang C, Sun J, Li L, Zheng J, Wang C, Zhao Y, Yun D, Jia M, Wu Z, Liang H, Li W, Hu T, Guo R, Xiao L, Zou Y, Liu Z.   +15 more
europepmc   +4 more sources

Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine. [PDF]

Pediatr Res, 2020
Necrotizing enterocolitis (NEC), a necrotic inflammation of the intestine, represents a major health problem in the very premature infant. Although prevention is difficult, the combination of ingestion of maternal-expressed breastmilk in conjunction with a probiotic provides the best protection.
Meng D, Sommella E, Salviati E, Campiglia P, Ganguli K, Djebali K, Zhu W, Walker WA.   +7 more
europepmc   +6 more sources

Indole-3-lactic acid protects the gut vascular barrier following intestinal ischemia injury through AhR/Nrf2/STAT3 mediated claudin 2 downregulation. [PDF]

Cell Commun Signal
Jia Y, He M, Wang F, Zhan Y, Deng Q, Shen J, Wang X, Ran Q, Huang W, Ling Y, Wen S.   +10 more
europepmc   +5 more sources

Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity [PDF]

Cell Metabolism, 2023
Previous studies have shown that Lactobacillus species play a role in ameliorating colorectal cancer (CRC) in a mouse model. However, the underlying mechanisms remain largely unknown. Here, we found that administration of a probiotic strain, Lactobacillus plantarum L168 and its metabolite, indole-3-lactic acid, ameliorated intestinal inflammation ...
Qingqing Zhang, Qing Zhao, Tao Li, Longya Lu, Fei Wang, Hong Zhang, Zhi Liu, Huihui Ma, Qihui Zhu, Jingjing Wang, Xuemei Zhang, Yang Pei, Qisha Liu, Yuyu Xu, Jinlong Qie, Xiaoting Luan, Zhibin Hu, Xingyin Liu   +17 more
openalex   +3 more sources

Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp [PDF]

Applied and Environmental Microbiology, 1979
Fifty-one strains of the genus Bifidobacterium have been found to accumulate indole-3-lactic acid in culture broth. The isolated metabolite was identified through mass and nuclear magnetic resonance spectroscopy. All the microorganisms tested, as resting cells, have been shown to be able to convert L-tryptophan into L-indole-3-lactic acid.
Fabrizio Aragozzini, Annamaria Ferrari, Novella Pacini, Roberto Gualandris   +3 more
openalex   +3 more sources

Lactiplantibacillus plantarum DPUL-S164 regulate aryl hydrocarbon receptors signaling to ameliorate dextran sodium sulfate-induced intestinal barrier damage by producing indole-3-lactic acid in a tryptophan-rich diet [PDF]

Food Science and Human Wellness
The aim of this paper was to study the effect of combination of Lactobacillus strains and tryptophan (Trp)-rich diet on the intestinal barrier function of Balb/c mice exposed to a cocktail of antibiotics and dextran sodium sulfate.
Arong Wang, Dashuai He, Tieqi Wang, Cheng Guan, Guangqing Mu, Yanfeng Tuo   +5 more
doaj   +2 more sources

Activation of aryl hydrocarbon receptor signaling by indole-3-lactic acid from Bacillus velezensis DS2 reinforces gut mucosal immunity and attenuates inflammaging in aged mice. [PDF]

Immun Ageing
Liu X, Zhou J, Hou Q, Zhou Z, Bai Y.
europepmc   +2 more sources

Microbiome-Derived Indole-3-Lactic Acid Attenuates <i>Cutibacterium Acnes</i>-Induced Inflammation via the Aryl Hydrocarbon Receptor Pathway. [PDF]

Int J Mol Sci
Lee SG, Chau NH, Ham S, Baek Y, Nguyen NH, Kim SH, Lee YI.   +6 more
europepmc   +3 more sources