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The mechanism of action of indole-3-propionic acid on bone metabolism
Food & FunctionIPA binds to AhR and PXR receptors, regulating bone metabolic disorders.
Huimin Xu, Yingzhe Luo, Yi An, Xi Wu
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Journal of Agricultural and Food Chemistry, 2020
Destruction in intestinal barrier is concomitant with the intestinal diseases. There is growing evidence that tryptophan-derived intestinal bacterial metabolites play a critical role in maintaining the balance of intestinal mucosa. In this study, the Caco-2/HT29 coculture model was used to evaluate the effect of indole-3-propionic acid (IPA) on the ...
Jiaojiao Li +5 more
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Destruction in intestinal barrier is concomitant with the intestinal diseases. There is growing evidence that tryptophan-derived intestinal bacterial metabolites play a critical role in maintaining the balance of intestinal mucosa. In this study, the Caco-2/HT29 coculture model was used to evaluate the effect of indole-3-propionic acid (IPA) on the ...
Jiaojiao Li +5 more
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Science China Life Sciences
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown.
Ziyi, Han +3 more
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The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown.
Ziyi, Han +3 more
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International Immunopharmacology
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease for which current therapeutic approaches still face many dilemmas, and targeting macrophage polarization and metabolism for the treatment of this disease is a potentially effective strategy.
Jiahong, Li +3 more
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Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease for which current therapeutic approaches still face many dilemmas, and targeting macrophage polarization and metabolism for the treatment of this disease is a potentially effective strategy.
Jiahong, Li +3 more
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Experimental Neurology, 2022
Increasing evidence highlights the importance of gut microbiota and its metabolites as an environmental factor affecting ischemic stroke. However, the role of microbial indole metabolites in ischemic stroke remains largely unknown. Here, we evaluated the effects and the underlying mechanism of indole-3-propionic acid (IPA) in a mouse model of acute ...
Yu, Xie +12 more
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Increasing evidence highlights the importance of gut microbiota and its metabolites as an environmental factor affecting ischemic stroke. However, the role of microbial indole metabolites in ischemic stroke remains largely unknown. Here, we evaluated the effects and the underlying mechanism of indole-3-propionic acid (IPA) in a mouse model of acute ...
Yu, Xie +12 more
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Journal of Agricultural and Food Chemistry
Cognitive disorders such as Alzheimer's disease (AD) are highly prevalent and place heavy burdens on society. Neuroinflammation is a driver of cognitive impairment, with no effective drugs. Indole 3-propionic acid (IPA) is a tryptophan metabolite mainly produced byClostridium sporogenes, which exhibits multiple functions, including antioxidant, anti ...
Zhizhong Hao +9 more
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Cognitive disorders such as Alzheimer's disease (AD) are highly prevalent and place heavy burdens on society. Neuroinflammation is a driver of cognitive impairment, with no effective drugs. Indole 3-propionic acid (IPA) is a tryptophan metabolite mainly produced byClostridium sporogenes, which exhibits multiple functions, including antioxidant, anti ...
Zhizhong Hao +9 more
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Acta Crystallographica Section C Crystal Structure Communications, 1998
The title compound, C 11 H 11 NO 2 , has a fully extended propionic acid side chain. The molecules are held together as dimers by centrosymmetric pairs of intermolecular hydrogen bonds between the carboxyl groups. The O...O distance is 2.649 (2) A.
N. Okabe, Y. Adachi
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The title compound, C 11 H 11 NO 2 , has a fully extended propionic acid side chain. The molecules are held together as dimers by centrosymmetric pairs of intermolecular hydrogen bonds between the carboxyl groups. The O...O distance is 2.649 (2) A.
N. Okabe, Y. Adachi
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Syntheses, structures and properties of complexes of indole-3-propionic acid
Transition Metal Chemistry, 2016Three complexes [Zn2(IPA)2(phen)4](HIPA)2(NO3)2·H2O (1), {[Zn(IPA)2(bipy)]·3H2O}n (2), and {[Mn(IPA)2(bipy)(H2O)]·2H2O}n (3) (HIPA = indole-3-propionic acid, phen = 1,10-phenanthroline, bipy = 4,4′-bipyridine) were synthesized and characterized by physico-chemical and spectroscopic methods.
Xiu-jun Deng +4 more
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Indole‐3‐propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus
Journal of Neuroscience Research, 2009AbstractTryptophan‐derived indole compounds have been widely investigated as antioxidants and as free‐radical scavengers. Indole‐3‐propionic acid (IPA), one of these compounds, is a deamination product of tryptophan. In the present study, we used Mongolian gerbils to investigate IPA's neuroprotective effects against ischemic damage and its ...
In Koo, Hwang +10 more
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Organic Preparations and Procedures International, 1981
(1981). TWO EFFICIENT SYNTHESES OF INDOLE-3-PROPIONIC ESTERS AND ACIDS. FURTHER APPLICATIONS OF MELDRUM'S ACID. Organic Preparations and Procedures International: Vol. 13, No. 1, pp. 39-48.
Diane S. Farlow +4 more
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(1981). TWO EFFICIENT SYNTHESES OF INDOLE-3-PROPIONIC ESTERS AND ACIDS. FURTHER APPLICATIONS OF MELDRUM'S ACID. Organic Preparations and Procedures International: Vol. 13, No. 1, pp. 39-48.
Diane S. Farlow +4 more
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