Results 171 to 180 of about 49,383 (204)

Role of indole-3-propionic acid, a gut microbiota-derived metabolite, in endothelial dysfunction

Atherosclerosis, 2023
Background and Aims: Indole-3-propionic acid (IPA) is a molecule pro- duced by the intestinal microbiota, after tryptophan ingestion. From the gut, IPA is absorbed through the intestinal barrier and enters the systemic circulation, where it plays several physiological roles, such as regulation of the intestinal barrier function, antioxidant and anti ...
Geddo, F., Boccellato, A., Querio, G., Antoniotti, S., Levi, R., Gallo, M. P.   +5 more
openaire   +2 more sources

One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy

Cell Host & Microbe
Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8+ T cells to augment immunotherapy at the pan-cancer level.
Zheshun, Pi, Weici, Liu, Wenjun, Mao
openaire   +2 more sources

Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects.

American Journal of Physiology - Gastrointestinal and Liver Physiology
Metabolites generated from the intestinal microbiota regulate local and distant tissues. One important metabolite generated from L-tryptophan is indole-3-propionic acid (IPA), which has been shown previously to regulate intestinal mucosal homeostasis in ...
K. Nieves, K. Flannigan, Elizabeth Hughes, Matthew Stephens, Andrew J. Thorne, Ameline Delanne, Kathryn Strayer, Darasimi Kola-Ilesanmi, Senya Wickramasinghe, Niloofar Mirzadzare, G. Baruta, Braedon McDonald, E. Cobo, Bjöern Petri, Sridhar Mani, Simon A Hirota   +15 more
semanticscholar   +1 more source

Carcinogen-Induced, Free Radical-Mediated Reduction in Microsomal Membrane Fluidity: Reversal by Indole-3-propionic Acid

Journal of Bioenergetics and Biomembranes, 2001
Chromium (Cr) is a well established carcinogen, with Cr(III) accounting for much of the intracellular oxidative damage that this transition metal induces. Indole-3-propionic acid (IPA), a melatonin-related molecule, is a reported antioxidant and free radical scavenger. Concentration (1, 10, 100, 500, or 1000 microM) and time (15, 30, 45, 60, or 90 min)-
M, Karbownik, J J, Garcia, A, Lewiński, R J, Reiter   +3 more
openaire   +2 more sources

Effect of Bacteria-Derived Indole-3-Propionic Acid (IPA) in murine primary Hepatocytes

2017
Die Leber des Menschen ist ein Organ mit erstaunlichen Selbstheilungskräften. Die Frage nach Faktoren, die Gesundheit und Regenerationspotential dieses Organs erhalten, stehen seit längerem im Zentrum des wissenschaftlichen Interesses. Anatomisch einzigartig erhält die Leber den Großteil ihrer Blutversorgung aus dem Darm.
openaire   +2 more sources

Garlic-Derived Exosome-Like Nanoparticles Enhance Gut Homeostasis in Stressed Piglets: Involvement of Lactobacillus reuteri Modulation and Indole-3-propionic Acid Induction.

Journal of Agricultural and Food Chemistry
The occurrence of pediatric diarrhea is frequently associated with inflammatory responses, compromised barrier function, and dysbiosis in the gut. These conditions are commonly triggered by stressors, similar to postweaning diarrhea observed in piglets ...
Xiyuan Liu, Xinyu Zhang, Haozhen Liu, Huiyang Fu, Yanan Liu, Yao Ge, Siwei Deng, Zhining Tang, Lihua Mei, Jiaxin Wang, Xuelian Liu, Ying Yang, Zhenlong Wu, Yun Ji   +13 more
semanticscholar   +1 more source

Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota‐Derived Indole‐3‐Propionic Acid

Allergy. European Journal of Allergy and Clinical Immunology
Barrier dysfunction and dysbiosis of the skin microbiota are two of the key factors in the pathogenesis of atopic dermatitis (AD). Phytic acid (PA) is a common constituent of high‐fiber foods, whereas its role in AD remains unelucidated.
Piao Wang, Lan Yang, Lu Chen, Xinyu Huang, Zhen Lin, Yue Li, Caiyu Qi, Tianren Xu, Jianglin Zhang, Min Qi, Biao Cheng, Junjie Wang, Zhiqi Hu, Gaofeng Wang   +13 more
semanticscholar   +1 more source

Abstract 4141327: Alternate Day Fasting Attenuates Arterial Thrombotic Risk via Increasing Indole-3-propionic acid

Circulation
Background: Arterial thrombotic disease has long been a crucial worldwide health concern. Metabolic disorders have been validated to enhance platelet reactivity, thereby augmenting the thrombotic risk. Recent investigations have highlighted the metabolic improving effect of alternate day fasting (ADF).
Ruijia Feng, Wenchao Yang, Guiyan Peng, Weiqi Feng, Ting Long, Zilun Li, Guangqi Chang, Kan Huang   +7 more
openaire   +1 more source

Untargeted metabolomics identifies indole-3-propionic acid to relieve Ang II-induced endothelial dysfunction in aortic dissection

Molecular and Cellular Biochemistry
Indole-3-propionic acid (IPA), a gut microbiota-derived metabolite of tryptophan, has been proven to fulfill an essential function in cardiovascular disease (CVD) and nerve regeneration disease. However, the role of IPA in aortic dissection (AD) has not been revealed.
Qi, Wang, Hui, Lv, Mierxiati, Ainiwan, Gulinazi, Yesitayi, Asiya, Abudesimu, Dilixiati, Siti, Aliya, Aizitiaili, Xiang, Ma   +7 more
openaire   +2 more sources

Bifidobacterium breve M-16V Alleviates Cow's Milk Allergy in a Mouse Model via Gut Microbiota-Derived Indole-3-Propionic Acid-Aryl Hydrocarbon Receptor Signaling Axis.

Allergy. European Journal of Allergy and Clinical Immunology
BACKGROUND Gut microbiota plays a crucial role in the development of food allergy (FA), and probiotic intervention is a promising therapeutic strategy targeting the gut microbiota.
Huming Shao, Fangfang Min, Tianliang Bai, Zhongliang Wang, Yan Liu, Fan Yang, Zhongxia Li, Can Di, Min Lin, Xin Li, Hongbing Chen   +10 more
semanticscholar   +1 more source