Results 191 to 200 of about 329,198 (291)

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid. [PDF]

Appl Microbiol Biotechnol
Konishi H, Matsui R, Okamura T, Imahase A, Kobayashi T, Nishiyama H.   +5 more
europepmc   +1 more source

Electrocatalytic Annulation–Iodosulfonylation of Indole‐Tethered 1,6‐Enynes to Access Pyrrolo[1,2‐a]indoles [PDF]

Ya‐Yu Yuan, Xi Chen, J. Wang, Shenghu Yan, Yu‐Ting Wang, Yue Zhang, Jianwu Liu, Hang‐Dong Zuo   +7 more
openalex   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Auxin accumulation in cereals after infection by Fusarium graminearum: putative biosynthetic pathways and preferences. [PDF]

Stress Biol
Shang H, Ji B, Ouellet T, Li G, Li B, Chen X, Luo K.   +6 more
europepmc   +1 more source

Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold

European Journal of Inorganic Chemistry, EarlyView.
A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy, Marcos R. Conde González, Jürgen H. Gross, Franziska Thomas   +3 more
wiley   +1 more source

RETRACTED: Ahmad et al. Mechanisms and Therapeutic Implications of Cell Death Induction by Indole Compounds. <i>Cancers</i> 2011, <i>3</i>, 2955-2974. [PDF]

Cancers (Basel)
Ahmad A, Sakr WA, Rahman KMW.
europepmc   +1 more source

Consecutive (Pseudo‐)Four‐Component Synthesis of Meta‐ and Ortho‐Biaryl Triarylamines with Tunable Emission and Redox Properties

European Journal of Organic Chemistry, EarlyView.
The combination of Suzuki and Buchwald–Hartwig coupling in (pseudo‐)four‐component reactions paves an efficient one‐pot route to twisted, redox‐active triarylamine (TAA) emitters. Biaryl substitution patterns and para‐substituents serve as key levers for tuning redox potentials, as well as absorption and emission energies, complemented and, by time ...
Regina Kohlbecher, Tim Lippert, Hendrik Schröder, Dustin N. Jordan, Christoph Janiak, Thomas J. J. Müller   +5 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Pseudo-Natural Products Inspired by Aryloctahydroindole Alkaloids. [PDF]

ChemMedChem
Greiner LC, Bernal FA, Thavam S, Brachthäuser M, Sievers S, Ziegler S, Waldmann H.   +6 more
europepmc   +1 more source

Comparison of Metabolic Features of Indole-3-Acetic Acid in the Gut among Five Species of Heteropterous Insects

, 1981
Koji Hori
openalex   +2 more sources