Results 61 to 70 of about 329,198 (291)

Chronic Inflammatory Enteropathy and Low-Grade Intestinal T-Cell Lymphoma Are Associated with Altered Microbial Tryptophan Catabolism in Cats

Animals, 2023
Chronic inflammatory enteropathy (CIE) and low-grade intestinal T-cell lymphoma (LGITL) are common chronic enteropathies (CE) in cats. Enteric microbiota dysbiosis is implicated in the pathogenesis of CE; however, the mechanisms of host–microbiome ...
Patrick C. Barko, David A. Williams, Yu-An Wu, Joerg M. Steiner, Jan S. Suchodolski, Arnon Gal, Sina Marsilio   +6 more
doaj   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Novel approach to bis(indolyl)methanes using nickel nanoparticles as a reusable catalyst under solvent-free conditions [PDF]

Journal of the Serbian Chemical Society, 2013
A nanosized Nickel as catalyst has been developed for the electrophilic substitution reactions of indole with variousaromatic aldehydes under solvent-free conditions to afford the corresponding bis(indolyl)methanes in high to excellent yields.
Olyaei Abolfazl, Vaziri Mohsen, Razeghi Reza, Bahareh Shams, Bagheri Hasan   +4 more
doaj   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Indole produced during dysbiosis mediates host–microorganism chemical communication

eLife, 2023
An imbalance of the gut microbiota, termed dysbiosis, has a substantial impact on host physiology. However, the mechanism by which host deals with gut dysbiosis to maintain fitness remains largely unknown.
Rui-Qiu Yang, Yong-Hong Chen, Qin-yi Wu, Jie Tang, Shan-Zhuang Niu, Qiu Zhao, Yi-Cheng Ma, Cheng-Gang Zou   +7 more
doaj   +1 more source

On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. [PDF]

, 2016
A Friedel-Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations
Curtin, Brice H, Harran, Patrick G, Houk, KN, Lawson, Kenneth V, Rose, Tristin E, Simon, Adam   +5 more
core   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Structure–Activity Relationship Studies of Indolglyoxyl-Polyamine Conjugates as Antimicrobials and Antibiotic Potentiators

Pharmaceuticals, 2023
Antibiotic resistance is a growing global health threat, requiring urgent attention. One approach to overcome antibiotic resistance is to discover and develop new antibiotic enhancers, molecules that work with legacy antibiotics to enhance their efficacy
Melissa M. Cadelis, Tim Liu, Kenneth Sue, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp   +6 more
doaj   +1 more source

Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source