Matrix-Assisted DOSY for Analysis of Indole Alkaloid Mixtures [PDF]
Molecules, 2021 Diffusion-ordered spectroscopy (DOSY) is a powerful tool for investigating mixtures and identifying peaks of chemical components. However, similar diffusion coefficients of the components, particularly for complex mixtures that contain crowded resonances,
Yu-Lin You +3 more
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Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in ...
Netz, Natalie, Opatz, Till
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Modular assembly of indole alkaloids enabled by multicomponent reaction
Nature Communications, 2023 Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li +4 more
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Natural Product-Oriented Photo-Induced Denitrogenative Annulations of 1-Alkenylbenzotriazoles
Molecules, 2023 The photo-induced denitrogenative annulations of a variety of 1-alkenylbenzotriazoles were investigated. By judiciously manipulating the structural variations of 1-alkenylbenzotriazoles, two characteristic polycyclic skeletons associated with monoterpene
Zhiguo Wang +3 more
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Ochroborbone, A New Cytotoxic Indole Alkaloid from
Natural Product Communications, 2017 A new monoterpenoid indole alkaloid, ochroborbone ( 1 ), along with five known alkaloids ( 2–6 ), were isolated from the stems and leaves of Ochrosia borbonica .
Yan-Ping Liu +7 more
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Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice [PDF]
, 2018 Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T.
Akinyeke, Tunde +11 more
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Binary Stress Induces an Increase in Indole Alkaloid Biosynthesis in Catharanthus roseus
Frontiers in Plant Science, 2015 Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis
Wei eZhu +5 more
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Indole-Based Tubulin Inhibitors: Binding Modes and SARs Investigations
Molecules, 2022 Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through interfering with the normal structure and function of microtubules, forming spindle filaments.
Sheng Tang +4 more
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Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]
, 2017 Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A +2 more
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A New Erythrinan Alkaloid Glycoside from the Seeds of Erythrina crista-galli
Molecules, 2017 A new Erythrina alkaloid glycoside, named erythraline-11β-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid.
Qing-Wei Tan +3 more
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