Results 51 to 60 of about 429,874 (275)

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Simple indole alkaloids and those with a non-rearranged monoterpenoid unit. [PDF]

, 2014
Covering: 2010-2011. Previous review: Nat. Prod. Rep. 2010, 27, 1630-1680This review covers the literature on simple indole alkaloids and those with a non-rearranged monoterpenoid unit from the beginning of 2010 up to the end of 2011, which includes ...
9000318134967, 9000014453717, 45075, 9000005189344, 石倉, 稔, 9000248213387, 45538, 町支, 臣成, 45614, 45081, 阿部, 匠, 日比野, 俐   +11 more
core  

Pharmacology of Macroalgae Alkaloids [PDF]

, 2013
Constituents of marine algae gained importance in the last four decades due to the growing interest in their potential for medicinal use. Till today, 44 alkaloids were isolated from macroalgae; some of which were reported to induce important ...
Hüseyin Erdugan, Burak Coban, Kasım Cemal Güven, Kaleağasioğlu, Ferda, Erdugan, Hüseyin, Ekrem Sezik, Güven, Kasim Cemal, Sezik, Ekrem, Coban, Burak, Ferda Kaleağasıoğlu   +9 more
core   +1 more source

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

Marine Drugs, 2014
Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth.
Xia Yan, Xi-Xiang Tang, Lin Chen, Zhi-Wei Yi, Mei-Juan Fang, Zhen Wu, Ying-Kun Qiu   +6 more
doaj   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Investigação fitoquímica e biológica da espécie: Esenbeckia leiocarpa Engl. [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.A investigação fitoquímica biomonitorada das cascas da espécie Esenbeckia leiocarpa confirmou a presença de ...
Horst, Heros
core  

Structural Elucidation and Cytotoxic Activity of New Monoterpenoid Indoles from Gelsemium elegans

Molecules, 2023
Two new monoterpenoid indole alkaloids, gelselegandines F (1) and G (2), were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations.
Da Song, Jia-Jun Liang, Shi-Biao Pu, Pan-Pan Zhang, Yun-Lin Peng, Xia Liu, Ting-Ting Feng, Xiang Pu, Ying Zhou, Xiong-Wei Liu, Xin Wei   +10 more
doaj   +1 more source

Synthesis and Structures of Novel Chiral Cyclic Hypervalent Iodine(III) Reagents for Metal‐Free Ligand‐Transfer Reactions

Chemistry – A European Journal, EarlyView.
Several new chiral cyclic hypervalent iodine(III) reagents have been synthesized and characterized. Carbon‐based ligands were successfully installed onto the hypervalent iodine centers, giving thus access to novel chiral cyano‐, trifluoromethyl‐ or alkynyl‐bearing λ3‐iodanes.
Emmanuel Valzer, Jean‐Marc Sotiropoulos, Karinne Miqueu, Laurent Pouységu, Stéphane Quideau   +4 more
wiley   +1 more source

Lolitrem B and Indole Diterpene Alkaloids Produced by Endophytic Fungi of the Genus Epichloë and Their Toxic Effects in Livestock

Toxins, 2016
Different group of alkaloids are produced during the symbiotic development of fungal endophytes of the genus Epichloë in grass. The structure and toxicity of the compounds vary considerably in mammalian herbivores and in crop pests.
Guerre Philippe
doaj   +1 more source

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source