Results 71 to 80 of about 31,700 (240)

Protective Effects of Potential Probiotic Pediococcus acidilactici 100 Against Multi‐Drug‐Resistant Diarrheal Escherichia coli Strains Induced Changes in Caenorhabditis elegans Model System

Food Safety and Health, EarlyView.
This study shows the protective effects of potential probiotic strain of Pediococci strains against diarrheal Escherichia coli strains in Caenorhabditis elegans model system. The E. coli strains resulted in severe morphological and physiological damage to the worm whereas the probiotic interventions were able to reduce these damages.
Gunjan Sadera, Anjali Jaglan, Lappasi Mohanram VenkataKrishna, Krishnaswamy Balamurugan, Gunjan Goel   +4 more
wiley   +1 more source

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Is the endophyte‐based plant protection against aphids mediated by changes in the insect microbiome?

Insect Science, EarlyView.
We showed that the fungal endophyte Epichloë strain AR37 increased the plant resistance against aphids via the production of indole diterpene alkaloids. The reduction in aphid performance was not associated with changes in abundance/composition/diversity of the insect's bacterial microbiota, but additional endophyte effects on this microbiota cannot be
Daniel A. Bastías, Luis Carvalho, Ruy Jáuregui, Richard D. Johnson, Wei Zhang, Pedro E. Gundel   +5 more
wiley   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, EarlyView.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Pangenome analysis reveals the genetic mechanism underlying high‐altitude adaptation in Qinghai–Xizang (Tibet) Plateau Rhododendron

Journal of Integrative Plant Biology, EarlyView.
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou, Zhongping Xu, Fanhuang Zeng, Haiyu Sang, Zhenhua Liu, Miao Sun, Qiang Fu, Kaige Zhao, Daming Tan, Manzhu Bao, Shuangxia Jin, Xiuqun Liu   +11 more
wiley   +1 more source

Three New Indole Alkaloids from Tabernaemontana divaricata

Natural Products and Bioprospecting, 2018
Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae).
Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai   +4 more
doaj   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

Alternative Protein Sources in Poultry and Pig Nutrition—A Review

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Proteins are an essential nutrient for the viability of all animals, enabling organisms to grow, regenerate and defend themselves against pathogenic organisms. Soybean and soybean‐based materials are commonly used to supplement protein in animal nutrition.
Lukáš Čumplík, Dana Zálešáková, Jakub Novotný, Lenka Kudlová, Leoš Pavlata, Ondřej Šťastník   +5 more
wiley   +1 more source