Results 71 to 80 of about 13,614 (219)

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights

Journal of Genetic Engineering and Biotechnology
Mitragyna species, known for their diverse traditional uses across various Asian countries, have gained scientific interest due to their pharmacological properties and rich phytochemical composition.
Karma Sherub Wangmo, Juraithip Wungsintaweekul, Zhengkang Zhu, Mengquan Yang, Amit Jaisi   +4 more
doaj   +1 more source

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope
High‐throughput screening (HTS) of compound libraries is a primary driver in the discovery of therapeutic leads. HTS libraries are largely composed of structurally simple organic compounds bearing few, if any, complex molecules which limits the kinds of ...
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
doaj   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

Glyphosate residues in soil alter herbivore‐induced plant volatiles and affect predatory insect behaviour

Plant Biology, EarlyView.
Herbicide residues in soil disrupt plant–insect signalling, reducing the effectiveness of biological pest control. Abstract Plants under herbivore attack emit distinct blends of herbivore‐induced plant volatiles (HIPVs) which serve as signalling cues for predatory insects.
B. Fuchs, J. D. Blande, V. Weijola
wiley   +1 more source

Indole Alkaloids from and Growing in Turkey

Natural Product Communications, 2012
A new indole alkaloid, 11-hydroxypolyneuridine, was isolated from Vinca major subsp. major L. and the known indole alkaloids vallesiachotamine and isovallesiachotamine from Vinca minor L.
Fatemeh Bahadori, Gülaçtι Topçu, Mehmet Boǧa, Ayla Türkekul, Ufuk Kolak, Murat Kartal   +5 more
doaj   +1 more source

Oxygen Attachment Dissociation of Protonated Reserpine and Its Analogs

Rapid Communications in Mass Spectrometry, Volume 40, Issue 14, 30 July 2026.
ABSTRACT Rationale Carbon–carbon double bonds are ubiquitous structural motifs in natural products and pose a key challenge in locating their presence in analytes via MS‐based methods. Here, we use the alkaloid reserpine as a model system to examine whether OAD reactions can locate quaternary double bonds embedded in fused multicyclic structures ...
Jack G. Li, Chris J. Bowen, Bun Chan, Adam W. E. Stewart, Hidenori Takahashi, Richard A. J. O'Hair   +5 more
wiley   +1 more source

The Potential of Indole Alkaloids in Bone Health and Osteoporosis Management

Applied Sciences
Indole alkaloids, a class of plant-derived nitrogen-containing compounds, have emerged as promising candidates for osteoporosis treatment. Their favorable biocompatibility profile demonstrated efficacy in preclinical models, and low reported toxicity ...
Anna Caruso, Virginia Caira, Hussein El-Kashef, Carmela Saturnino   +3 more
doaj   +1 more source