Results 91 to 100 of about 429,874 (275)

Isoquinoline Alkaloids and Indole Alkaloids Attenuate Aortic Atherosclerosis in Apolipoprotein E Deficient Mice: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2018
Background: Several studies have attempted to relate the bioactive alkaloid with atherosclerotic cardiovascular diseases prevention in animal models, providing inconsistent results.
Yibing Zhang, Yibing Zhang, Min Li, Xiangjun Li, Tong Zhang, Meng Qin, Liqun Ren   +6 more
doaj   +1 more source

Chemical Studies of Indole Alkaloids

YAKUGAKU ZASSHI, 1995
Up to now, more than two thousands indole alkaloids having structural variety have been found from the three families of Gentianales: Loganiaceae, Apocynaceae, and Rubiaceae plants. These compounds generally possess characteristic biological activities and many of them are utilized for the medicinal purpose and for the lead-compounds to develop new ...
openaire   +3 more sources

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Antimicrobial Activities of Indole Alkaloids from

Natural Product Communications, 2011
Tabernaemontana catharinensis root bark ethanol extract, EB2 fraction and the MMV alkaloid (12-methoxy-4-methylvoachalotine) were evaluated for their antimicrobial activities. T.
Maria Rita Furquini Medeiros, Luiz Afonso de Melo Prado, Vanessa Colnaghi Fernandes, Sérgio Souza Figueiredo, Juliana Coppede, Juliana Martins, Giovana Maria Lanchoti Fiori, Nilce Maria Martinez-Rossi, Rene Oliveira Beleboni, Silvia Helena Taleb Contini, Paulo Sérgio Pereira, Ana Lúcia Fachin   +11 more
doaj   +1 more source

Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review

Frontiers in Pharmacology, 2017
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects.
H. Hamid, A. Ramli, M. Yusoff
semanticscholar   +1 more source

Nondefense functions of plant specialized metabolites: ecological phenomena, molecular mechanisms, and evolutionary implications

New Phytologist, EarlyView.
Nonexhaustive overview of empirically validated nondefense functions caused by or correlated with variation in four well‐studied classes of plant specialized metabolites (PSMs) – glucosinolates (green text), alkaloids (blue text), terpenoids (yellow text), and flavonoids/polyphenols (purple text) – separated into different categories of nondefense ...
Lauren N. Carley
wiley   +1 more source

A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights

Journal of Genetic Engineering and Biotechnology
Mitragyna species, known for their diverse traditional uses across various Asian countries, have gained scientific interest due to their pharmacological properties and rich phytochemical composition.
Karma Sherub Wangmo, Juraithip Wungsintaweekul, Zhengkang Zhu, Mengquan Yang, Amit Jaisi   +4 more
doaj   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source

Potential antimalarial activity of indole alkaloids [PDF]

, 2008
peer reviewedNew antimalarial treatments are now urgently required, following the emergence of resistance to the most used drugs. Natural products contribute greatly to the therapeutic arsenal in this area, including artemisinin and quinine (and ...
Angenot, Luc, Frederich, Michel, Tits, Monique   +2 more
core   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source