Results 101 to 110 of about 13,614 (219)

Natural Alkaloids as Antimicrobial Agents: Mechanisms, Potentials and Challenges

Molecules
Antimicrobial resistance (AMR) poses a significant global health threat, with multidrug-resistant pathogens undermining the effectiveness of conventional antibiotics. Natural alkaloids, a diverse group of nitrogen-containing compounds mainly derived from
Xi-Zhong Zhang, Ming-Xia Chen, Rui Hou, Wan-Qin Wang, Zhen-Dan He, Jie-Shu You, Xun Song   +6 more
doaj   +1 more source

Functional Metagenomics Insights Into the Allium ampeloprasum Rhizosphere Microbiome Under Different Fertilization Regimes

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Shotgun metagenomic sequencing was used to characterize the functional potential of the Allium ampeloprasum rhizosphere microbiome under chemical fertilizer (G1), biofertilizer (G2), and unfertilized (Bulk) soil (G3) management practices. This study revealed that different fertilization regimes altered microbial functional profiles.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

Synthesis and Activity Evaluation of Vinpocetine-Derived Indole Alkaloids. [PDF]

Molecules, 2023
Dong ZC, Shi Y, Zheng LL, Tian YP, Yang J, Wei Y, Zhou Y, Pan BW.   +7 more
europepmc   +1 more source

A Complete Genome Resource and Bio‐Control Activity of Soil‐Isolated Pseudomonas citronellolis Strain M03 Against Onion‐Pathogenic Burkholderia Species

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Pseudomonas citronellolis M03, isolated from field soil, was sequenced and its genome revealed ten biosynthetic clusters, including siderophore NRPS. Phenotypic assays showed strong antagonism against onion‐pathogenic Burkholderia spp., reducing B.
Kephas Mphande, Michelle Pena MacLellan, Anoop Anand Malik, Bhabesh Dutta   +3 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Fermentation and Enzymatic Pre‐Treatments to Modulate Sensory Properties of Extruded Plant‐Based Meat Alternatives

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Fermentation, enzymatic hydrolysis, and enzymatic crosslinking are emerging pre‐treatments to improve the sensory properties of extruded plant‐based meat alternatives. This review critically examines current literature to identify underlying mechanisms, benefits, and key research gaps associated with these pre‐treatments.
Ravinder Singh, Michel Aliani, Warren Blunt, Filiz Koksel   +3 more
wiley   +1 more source

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast. [PDF]

Nat Chem Biol, 2023
Bradley SA, Lehka BJ, Hansson FG, Adhikari KB, Rago D, Rubaszka P, Haidar AK, Chen L, Hansen LG, Gudich O, Giannakou K, Lengger B, Gill RT, Nakamura Y, de Bernonville TD, Koudounas K, Romero-Suarez D, Ding L, Qiao Y, Frimurer TM, Petersen AA, Besseau S, Kumar S, Gautron N, Melin C, Marc J, Jeanneau R, O'Connor SE, Courdavault V, Keasling JD, Zhang J, Jensen MK.   +31 more
europepmc   +1 more source

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez   +2 more
wiley   +1 more source

Advances in Metabolic Engineering of Plant Monoterpene Indole Alkaloids. [PDF]

Biology (Basel), 2023
Salim V, Jarecki SA, Vick M, Miller R.
europepmc   +1 more source

Genome‐wide analysis of the AP2/ERF gene family in Rheum officinale Baill.: Evolution and expression profiling during plant development, abiotic stresses, and exogenous hormone responses

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract The APETALA2/ethylene‐responsive factor (AP2/ERF) superfamily plays a central role in plant metabolism, stress responses, and hormone signaling. Rheum officinale Baill. is an important traditional medicinal plant whose roots and rhizomes are rich in anthraquinones and other secondary metabolites.
Jing Tang, Gao‐chang Cui, Heng Pan, Hui Lu, Yi‐min Li, Feng Yan, Jing Gao, Liang Peng, Xiao‐chen Hu, Gang Zhang   +9 more
wiley   +1 more source