Results 81 to 90 of about 13,614 (219)

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Unveiling the impact of nitrogen deficiency on alkaloid synthesis in konjac corms (Amorphophallus muelleri Blume)

BMC Plant Biology
Background Konjac corms are known for their alkaloid content, which possesses pharmacological properties. In the primary cultivation areas of konjac, nitrogen deficiency is a common problem that significantly influences alkaloid synthesis.
Ying Qi, Penghua Gao, Shaowu Yang, Lifang Li, Yanguo Ke, Yongteng Zhao, Feiyan Huang, Lei Yu   +7 more
doaj   +1 more source

Inhibition of jasmonic acid‐isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis

New Phytologist, Volume 251, Issue 1, Page 424-437, July 2026.
Summary Jasmonates (JAs)‐mediated pathways are central signaling hubs in plant defense responses. However, the identification of mobile and nonmobile signals involved in downstream systemic signaling is still less studied. Here, we investigate the role of the jasmonic acid‐isoleucine (JA‐Ile) conjugating enzyme, JAR1, in shifting wound‐induced local ...
Ming Zeng, Axel Mithöfer
wiley   +1 more source

Mitotic Block of Human Blood Cells by Vinca herbacea, Catharanthus roseus and Colchicine Alkaloids [PDF]

Journal of Medicinal Plants and By-products, 2018
Catharanthus roseus (L.) G.Don is a plant which produces anticancer and anti-mitotic indole alkaloids. Colchicine is an anti-mitotic drug. Anti-mitotic effects of Vinca herbacea Waldst. & Kit. indole alkaloids is unknown.
Babak Delnavaz Hashemloian, Azra Ataei Azimi   +1 more
doaj  

1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth, Maruti Mali, Fabienne Berrée   +2 more
wiley   +1 more source

Three New Indole Alkaloids from Tabernaemontana divaricata

Natural Products and Bioprospecting, 2018
Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae).
Yan Deng, Mei-Fen Bao, Bao-Bao Shi, Jing Wu, Xiang-Hai Cai   +4 more
doaj   +1 more source

Formation of Nudicaulins In Vivo and In Vitro and the Biomimetic Synthesis and Bioactivity of O-Methylated Nudicaulin Derivatives

Molecules, 2018
Nudicaulins are yellow flower pigments accounting for the color of the petals of Papaver nudicaule (Papaveraceae). These glucosidic compounds belong to the small group of indole/flavonoid hybrid alkaloids.
Bettina Dudek, Florian Schnurrer, Hans-Martin Dahse, Christian Paetz, Anne-Christin Warskulat, Christiane Weigel, Kerstin Voigt, Bernd Schneider   +7 more
doaj   +1 more source

Population‐Specific Chemotypes in Pseudomisopates rivas‐martinezii (Sanchez Mata) Güemes From La Serrota and Gredos Massifs (Iberian Central Range)

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Pseudomisopates rivas‐martinezii, a critically endangered Iberian endemic, reveals population‐specific chemotypes when analyzed by elemental analysis, FTIR, and GC–MS. Underground tissues from both populations share a convergent histidine‐derived metabolite profile, whereas aerial parts diverge markedly: La Serrota accumulates phenolic derivatives from
Eva Sánchez‐Hernández, María Elena Amat, Mario Cano‐Pérez, Vicente González‐García, Jesús Martín‐Gil, Pablo Martín‐Ramos   +5 more
wiley   +1 more source

Structural‐to‐Functional Complexity Transformations Enabled by Bridged Polyheterocycles: Access to Cis‐1,3‐Diamines and Amino‐Alcohols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu, Erica Benedetti, Laurent Micouin   +2 more
wiley   +1 more source