Results 171 to 180 of about 1,668,623 (259)

Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors. [PDF]

Bioorg Med Chem
Acharya B, Saha D, Garcia Garcia N, Armstrong D, Jabali B, Hanafi M, Frett B, Ryan KR.   +7 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria. [PDF]

Commun Biol
Chandal N, Kalia R, Dey A, Tambat R, Mahey N, Jachak S, Nandanwar H.   +6 more
europepmc   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Author Correction: Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives. [PDF]

Sci Rep
Siddique S, Ahmad KR, Nawaz SK, Raza AR, Ahmad SN, Ali R, Inayat I, Suleman S, Kanwal MA, Usman M.   +9 more
europepmc   +1 more source

Remote C6-Selective Ruthenium-Catalyzed C–H Alkylation of Indole Derivatives via σ-Activation

, 2017
Jamie A. Leitch, Claire L. McMullin, M. Mahon, Yunas Bhonoah, C. Frost   +4 more
semanticscholar   +1 more source

Mechanistic and Reactivity Insights into Diboron‐Mediated NN and NN Bond Scission

European Journal of Organic Chemistry, EarlyView.
This review highlights the emerging ability of diboron reagents to cleave both π‐bonded (N=N) and σ‐bonded (N—N) nitrogen–nitrogen linkages, integrating mechanistic understanding with recent synthetic applications. Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like
Raúl Valderrama‐Callejón, Inés Alonso, M. Belén Cid   +2 more
wiley   +1 more source

Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands. [PDF]

Biomolecules
Upadhyay S, Hailemariam AE, Mariyam F, Hafiz Z, Martin G, Kothari J, Farkas E, Sivaram G, Bell L, Tjalkens R, Safe S.   +10 more
europepmc   +1 more source

Iminodirhodium‐ and Iminocopper‐Catalyzed CH Activation: Chemoselective Oxidation of Alcohols and Aldehydes via Intermolecular Hydride Abstraction

European Journal of Organic Chemistry, EarlyView.
Chemoselective hydride abstractor iminometalloids, derived from O‐mesylacetoxime (MAO) using Rh2(II/II) or Cu(I) catalysts, can activate the C–Hα bonds of alcohols and aldehydes ultimately forming ketones, carboxylic acids, and esters even in the presence of C–H bonds with comparable bond strengths.
Raghunath Reddy Anugu, John R. Falck, Adeniyi M. Adebesin   +2 more
wiley   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, EarlyView.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source