Results 191 to 200 of about 1,668,623 (259)

New indole derivatives from endophytic fungus Colletotruchum sp. HK-08 originated from leaves of Nerium indicum. [PDF]

Chin Herb Med
Chen H, Zheng H, Cai C, Wang H, Gai C, Tan Z, Dai H, Mei W.   +7 more
europepmc   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives. [PDF]

ACS Pharmacol Transl Sci
Längle D, Wojtowicz-Piotrowski S, Priegann T, Keller N, Wesseler F, Reckzeh ES, Steffens K, Grathwol C, Lemke J, Flasshoff M, Näther C, Jonson AC, Link A, Koch O, Di Guglielmo GM, Schade D.   +15 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Evaluation of newly synthesized 2-(thiophen-2-yl)-1H-indole derivatives as anticancer agents against HCT-116 cell proliferation via cell cycle arrest and down regulation of miR-25. [PDF]

Sci Rep
Abdelazeem NM, Gouhar SA, Fahmy CA, Elshahid ZA, El-Hussieny M.   +4 more
europepmc   +1 more source

Switchable divergent synthesis of chiral indole derivatives via catalytic asymmetric dearomatization of 2,3-disubstituted indoles. [PDF]

RSC Adv
Liu T, Wang J, Xiao R, Zhao J.
europepmc   +1 more source

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Recent Development in Indole Derivatives as Anticancer Agent: A Mechanistic Approach

Anti-Cancer Agents in Medicinal Chemistry, 2021
BACKGROUND Cancer accounts for several deaths each year. There are multiple FDA approved drugs for cancer treatments. Due to the severe side effects and multiple drug resistance, the current drug therapies become ineffective.
Kamalpreet Kaur, Avadh Biharee, Vikas Jaitak   +2 more
exaly   +2 more sources

Discovery of novel indole derivatives containing dithioacetal as potential antiviral agents for plants

Pesticide Biochemistry and Physiology, 2020
Thirty unreported indole derivatives containing dithioacetal moiety were synthesized and evaluated for anti-plant viral activity. Bioassay results displayed that some of the target compounds showed better activities against tobacco mosaic virus (TMV ...
Chunle Wei, Lijun Zhao, Deyu Hu
exaly   +2 more sources

Indole derivatives

Chemistry of Heterocyclic Compounds, 1970
A. A. Semenov, K. I. Kuchkova, E. P. Styngach   +2 more
  +14 more sources