Results 201 to 210 of about 1,668,623 (259)

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity.

European journal of medicinal chemistry, 2023
In order to develop potential α-glucosidase inhibitors with antidiabetic activity, twenty-six indole derivatives containing thiazolidine-2,4-dione were synthesized.
Chunmei Hu, Bingwen Liang, Jinping Sun, Jiangyi Li, Zhuang Xiong, Shao-Hua Wang, Xuetao Xu   +6 more
semanticscholar   +1 more source

Gut microbiota-derived indole derivatives alleviate neurodegeneration in aging through activating GPR30/AMPK/SIRT1 pathway.

Molecular Nutrition & Food Research, 2023
SCOPE Tryptophan metabolites are closely related to neurological diseases, whereas, the underlying mechanism related to the alleviative effects of tryptophan metabolites on neurodegeneration in aging remains unclear.
Jia Yin, Yunhui Zhang, Xiaoxia Liu, Wanhua Li, Yaozhong Hu, Bowei Zhang, Shuo Wang   +6 more
semanticscholar   +1 more source

Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.

Accounts of Chemical Research, 2022
ConspectusCatalytic atroposelective syntheses of axially chiral compounds have stimulated extensive interest in multiple communities, such as synthetic chemistry, biochemistry, and materials science, because of the intriguing characteristics of ...
Honghao Zhang, F. Shi
semanticscholar   +1 more source

Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-Activity Relationships of Indole Derivatives: A Review.

Mini-Reviews in Medical Chemistry, 2022
Indole (2,3-benzopyrrole) containing a pyrrolyl ring possesses the characteristic of electron-rich aromatic compounds. Indole occurs in the oil of jasmine and cloves, and coal tar.
Tianze Li, Hui Xu
semanticscholar   +1 more source

Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents.

Bioorganic & Medicinal Chemistry, 2021
The α- and β-tubulins are the major polypeptide components of microtubules (MTs), which are attractive targets for anticancer drug development. Indole derivatives display a variety of biological activities including antitumor activity. In recent years, a
Yudong Hong, Yuan-Yuan Zhu, Qiuqin He, Shuang‐Xi Gu   +3 more
semanticscholar   +1 more source

Therapeutic potential of indole derivatives as anti-HIV agents: A mini-review.

Current Topics in Medicinal Chemistry, 2021
Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is one of the leading causes of human deaths. The advent of different anti-HIV drugs over different disease progress has made AIDS/HIV from a deadly infection to ...
Qingtai Chen, Chongchong Wu, Jinjin Zhu, Enzhong Li, Zhi Xu   +4 more
semanticscholar   +1 more source

Studies on the biological activity of gem-difluorinated 3,3′-spirocyclic indole derivatives

Chinese Chemical Letters, 2021
The biological activities of a series of 3,3′-spirocyclic indole derivatives containing CF2, phosphine oxide, indole, and cyano functional groups were evaluated, and these derivatives were found to exhibit anti-TMV, fungicidal, and insecticidal ...
Qiang Wang, Hongjian Song, Qingmin Wang
semanticscholar   +1 more source

Fluorescence of indole derivatives

Experientia, 1967
Die Verwendung von 1N Natronlauge und Essigsaureanhydrid bei der Bestimmung von Indolderivaten mit Hilfe der Fluoreszenzmethode erlaubt eine gute Differenzierung zwischen 5-Methoxyindolderivaten (z.B. Melatonin) und anderen Indolen. Versuche zur Verwendung der neuen Methode in biologischem Material, z.B. Epiphysenschnitten, sind im Gange.
M G, Balemans, F C, van de Veerdonk
openaire   +2 more sources

Antiviral activity of indole derivatives

Antiviral Research, 2009
Unsymmetrical methylene derivatives 5 were prepared following a known method, by reaction of the Mannich bases of 2-naphthols 4 with indoles. All synthesized compounds were tested against a wide panel of viruses, since previous work showed that Mannich bases on 7-hydroxycoumarin 1 and unsymmetrical methylene derivatives 2 were endowed with some ...
GIAMPIERI M, BALBI A, MAZZEI M, LA COLLA P, IBBA, CRISTINA, LODDO, ROBERTA   +5 more
openaire   +4 more sources

Current scenario of indole derivatives with potential anti-drug-resistant cancer activity.

European journal of medicinal chemistry, 2020
Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment.
Yanshu Jia, Xiaoyue Wen, Yufeng Gong, Xuefeng Wang   +3 more
semanticscholar   +1 more source