Results 221 to 230 of about 1,668,623 (259)

Synthesis of N-substituted indole derivatives as potential antimicrobial and antileishmanial agents.

Bioorganic chemistry (Print), 2020
Leishmaniasis and microbial infections are two of the major contributors to global mortality and morbidity rates. Hence, development of novel, effective and safer antileishmanial and antimicrobial agents having reduced side effects are major priority for
S. Tiwari, Seema Kirar, U. Banerjee, K. B. Neerupudi, Sushma B Singh, A. Wani, P. Bharatam, I. Singh   +7 more
semanticscholar   +1 more source

Asymmetric Dearomatization of Indole Derivatives with N-Hydroxycarbamates Enabled by Photoredox Catalysis.

Angewandte Chemie, 2019
Dearomatization of indoles and their derivatives provides efficient synthetic routes for substituted indolines. In most cases, indoles serve as nucleophiles by reacting with electrophiles at the C3 position.
Yuan‐Zheng Cheng, Qingyang Zhao, Xiao Zhang, S. You   +3 more
semanticscholar   +1 more source

Oleanolic acid indole derivatives as novel α-glucosidase inhibitors: Synthesis, biological evaluation, and mechanistic analysis.

Bioorganic chemistry (Print), 2020
Research efforts have been directed to the development of oleanolic acid (OA) based α-glucosidase inhibitors and various OA derivatives showed improved anti-α-glucosidase activity.
Panpan Wu, Hao He, Hang Ma, Borong Tu, Jiahao Li, Shengzhu Guo, Silin Chen, N. Cao, Wende Zheng, Xiaowen Tang, Dongli Li, Xuetao Xu, Xi Zheng, Z. Sheng, W. David Hong, Kun Zhang   +15 more
semanticscholar   +1 more source

Electrooxidation enables selective dehydrogenative [4+2] annulation between indole derivatives.

Angewandte Chemie, 2020
Dearomative annulation of indoles has emerged as a powerful tool for preparing polycyclic indoline-based alkaloids. Compared with well-established methods towards five-membered ring fused-indolines, the six-membered ring fused-indolines are rarely ...
Chunlan Song, Kun Liu, Xu Jiang, Xin Dong, Yue Weng, Chien-Wei Chiang, A. Lei   +6 more
semanticscholar   +1 more source

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst.

Organic Letters, 2020
Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly ...
H. Egami, Ryo Hotta, Minami Otsubo, Taiki Rouno, Tomoki Niwa, K. Yamashita, Y. Hamashima   +6 more
semanticscholar   +1 more source

Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications

Current organic chemistry, 2020
Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities.
Dipayan Mondal, Pankaj Lal Kalar, S. Kori, S. Gayen, Kalpataru Das   +4 more
semanticscholar   +1 more source

Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA).

European journal of medicinal chemistry, 2020
Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and flimsy tissues diseases.
Hua-Li Qin, Jing Liu, Wan‐Yin Fang, L. Ravindar, K. P. Rakesh   +4 more
semanticscholar   +1 more source

Indole derivatives as agrochemicals: An overview

Chinese Chemical Letters, 2023
Ping Sun, Yuan-Qin Huang, Shunhong Chen, Xining Ma, Zhaokai Yang, Jian Wu   +5 more
semanticscholar   +1 more source

Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer.

Anti-Cancer Agents in Medicinal Chemistry, 2019
BACKGROUND Breast Cancer (BC) is the second most common cause of cancer related deaths in women. Due to severe side effects and multidrug resistance, current therapies like hormonal therapy, surgery, radiotherapy and chemotherapy become ineffective. Also,
K. Kaur, Vikas Jaitak
semanticscholar   +1 more source

Synthesis and antifouling evaluation of indole derivatives.

Ecotoxicology and Environmental Safety, 2019
Indole derivatives derived from the secondary metabolites of marine organisms possess the excellent antifouling property to inhibit the biofouling. These compounds and their analogues are simple in structure and have been proven to have low toxicity and ...
K. Feng, Chunhua Ni, Liangmin Yu, Wenjun Zhou, Xia Li   +4 more
semanticscholar   +1 more source