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Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies.

Current Drug Targets, 2020
Heterocyclic compounds play significant role in various biological processes of human body and many of them are in clinical use due to their diverse, chemical and biological properties.
Devendra Kumar   +5 more
semanticscholar   +1 more source

Indole derivatives as neuroprotectants

Life Sciences, 1999
It seems to be satisfactorily proved that reactive oxygen species (ROS) participate in numerous pathological processes in the nervous system (NS). Compounds able to interfere with the action of ROS might be useful in prevention and treatment of these pathologies.
openaire   +2 more sources

Synthesis and structural analysis of novel indole derivatives by XRD, spectroscopic and DFT studies

Journal of Molecular Structure, 2020
The indole derivatives have been getting immense interest to possess diverse applications in different fields. In present investigation, four novel indole based derivatives namely; 4,6-dimethoxy-2,3-diphenyl-1H-indole 3a, 4,5,6-trimethoxy-2,3-diphenyl-1H-
Sobia Tariq   +7 more
semanticscholar   +1 more source

Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole.

Journal of Agricultural and Food Chemistry
In this study, 24 indole derivatives containing 1,3,4-thiadiazole were discovered and synthesized. The target compounds' antifungal efficacy against 14 plant pathogenic fungal pathogens was then determined in vitro.
Bangcan He   +8 more
semanticscholar   +1 more source

Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.

Bioorganic chemistry (Print), 2019
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic compound with wide ranges of pharmacological activities due to different mechanisms of action. It is an superlative moiety in drug discovery with the sole property
A. Kumari, R. Singh
semanticscholar   +1 more source

Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities.

Current Medicinal Chemistry, 2020
BACKGROUND The indole framework is considered as one of the privileged structures in the area of medicinal chemistry and drug discovery because compounds containing this framework have shown to possess remarkable ability to bind with many receptors or ...
Gangireddy Sujeevan Reddy, M. Pal
semanticscholar   +1 more source

Indole derivatives

Chemistry of Heterocyclic Compounds, 1972
L. A. Aksanova   +2 more
  +8 more sources

Indole derivatives

Chemistry of Heterocyclic Compounds, 1971
N. N. Novikova   +4 more
  +7 more sources

Photocatalytic Intramolecular [2 + 2] Cycloaddition of Indole Derivatives via Energy Transfer: A Method for Late-Stage Skeletal Transformation

, 2020
Visible light-promoted dearomative [2 + 2] cycloaddition of indole derivatives tethered with olefins at the N1 position has been considered thermodynamically unfeasible due to the high triplet exci...
Zhijie Zhang   +11 more
semanticscholar   +1 more source

Synthesis of Difluoroalkylated Benzofuran, Benzothiophene, and Indole Derivatives via Palladium-Catalyzed Cascade Difluoroalkylation and Arylation of 1,6-Enynes.

Organic Letters, 2020
A novel and efficient method for the synthesis of difluoroalkylated benzofuran, benzothiophene, and indole derivatives via palladium-catalyzed aryldifluoroalkylation of 1,6-enynes with ethyl difluoroiodoacetate and arylboronic acids has been established.
Pengbo Zhang   +6 more
semanticscholar   +1 more source

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