Results 181 to 190 of about 1,668,623 (259)

Novel C3-Methylene-Bridged Indole Derivatives with and without Substituents at N1: The Influence of Substituents on Their Hemolytic, Cytoprotective, and Antimicrobial Activity. [PDF]

Int J Mol Sci
Babijczuk K, Berdzik N, Nowak D, Warżajtis B, Rychlewska U, Starzyk J, Mrówczyńska L, Jasiewicz B.   +7 more
europepmc   +1 more source

Electrochemical Three‐Component Synthesis of Heteroaryl Sulfonates

European Journal of Organic Chemistry, EarlyView.
An electrochemical, metal‐free three‐component strategy for direct C(sp2)─H sulfonation of electron‐rich heteroarenes using SO2 and alcohols is described. Utilizing inexpensive graphite electrodes and practical SO2 stock solutions under mild conditions, this method provides straightforward access to heteroaryl sulfonates from simple building blocks ...
Po‐Chung Chien, Harald Kelm, Georg Manolikakes   +2 more
wiley   +1 more source

Impact of Electronic Substitution and Planarization on the Photophysical Properties of 2‐(2′‐Hydroxyphenyl)benzoxazole or 2‐(2′‐Hydroxyphenyl)‐Dimethylindole

European Journal of Organic Chemistry, EarlyView.
We report the synthesis, structural characterization, and photophysical investigation of a series of Excited‐State Intramolecular Proton Transfer‐active HBO and HDMI derivatives. By varying heterocyclic cores, substituents, and ethynyl planarization, we establish structure–property relationships governing fluorescence behavior.
Mathieu Gervais, Timothée Stoerkler, Gilles Ulrich, Pascal Retailleau, Tristan Asset, Adèle D. Laurent, Denis Jacquemin, Julien Massue   +7 more
wiley   +1 more source

Capillary Electrophoresis With Amperometric Detection for Neurotransmitter Analysis: Principles, Electrode Materials, Methodologies, and Applications

ELECTROPHORESIS, EarlyView.
This review provides a comprehensive summary of monoamine neurotransmitter analysis by capillary electrophoresis with amperometric detection. Fundamental principles of amperometric detection, electrode positioning strategies, and approaches to high‐voltage decoupling are described, followed by a critical comparison of electrode materials, selection of ...
Petr Kubáň, Jiří Volánek, Nguyen Thi Thu Trang, Tran Dai Lam   +3 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. [PDF]

Bioorg Med Chem
Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS.   +7 more
europepmc   +1 more source

Spirobifluorene fusion in multiple resonance frameworks enables efficient pure‐red OLEDs with narrowband emission and suppressed efficiency roll‐off

FlexMat, EarlyView.
An orthogonal spirobifluorene‐fusion strategy is introduced for B/N/O‐alternated MR frameworks, enabling improved kRISC (5.46 × 103 s−1), high ΦPL (97%), and narrow‐band pure‐red emission. Vacuum‐evaporated OLEDs incorporating this emitter achieve an EQEmax >40% (FWHM = 36 nm) and exhibit exceptionally low efficiency roll‐off at high luminance ...
Yan‐Yun Jing, Han Wu, Xiaoling Xu, Sijie Xian, Jingsheng Miao, Xiaojun Yin, Chuluo Yang, Xiaosong Cao   +7 more
wiley   +1 more source

Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit Validation by Biological Assays. [PDF]

J Chem Inf Model
Pakamwong B, Thongdee P, Kamsri B, Phusi N, Taveepanich S, Chayajarus K, Kamsri P, Punkvang A, Hannongbua S, Sangswan J, Suttisintong K, Sureram S, Kittakoop P, Hongmanee P, Santanirand P, Leanpolchareanchai J, Spencer J, Mulholland AJ, Pungpo P.   +18 more
europepmc   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source